Nizoral Cream

(Ketoconazole)

The active ingredient in Nizoral Cream is ketoconazole. Ketoconazole is an azole antifungal, and its mechanism of action is that it blocks the synthesis of ergosterol, an essential component of fungal cell walls. This leads to fungal cell death and treatment of the fungal infection.

Follow all directions given to you by your doctor and read all documents provided, including the full Prescribing Information, FDA-Approved Product Labeling, Instructions for Use, and Medication Guide before using Nizoral Cream. However, the following is a synopsis of the general guidelines for the use of Nizoral Cream:

• Wash your hands after applying the cream, unless your hands are the treated area. Wash and dry the affected skin and surrounding areas before application. Apply a thin layer of Nizoral Cream to the affected area and surrounding skin. Gently rub the cream into the skin until it is absorbed.
• Nizoral Cream is typically used once or twice daily for 2 to 6 weeks, depending on the type of fungal infection being treated. Your healthcare professional will know what is best for you.
• Avoid contact with the eyes, mouth, and mucous membranes.
• Continue treatment for the full prescribed duration, even if symptoms improve.
• If a dose is missed, apply it as soon as you remember, unless it is close to the time of the next dose. Do not apply extra cream to make up for a missed dose.
• Nizoral Cream is for external use only. Avoid using occlusive dressings unless advised by a healthcare professional.

Some mild or common side effects of Nizoral Cream include:

• Burning or stinging at the application site.
• Itching or skin rash.
• Dryness or peeling of the skin.
• Mild redness.

Some individuals may experience serious side effects while using Nizoral Cream. These side effects may require immediate medical attention. If you experience any of the following, contact your healthcare provider or seek emergency medical help:

• Signs of an allergic reaction, such as hives or swelling of the face.
• Severe skin irritation or worsening rash.
• Swelling, blistering, or oozing at the application site.

These are not all of the possible side effects of Nizoral Cream. You should always seek medical advice from your healthcare provider for any questions or concerns about your medical condition or treatment. Read all patient information, medication guides, or drug information sheets that come with this medication. You can also report adverse effects to the Food and Drug Administration at www.fda.gov/medwatch or 1-800-FDA-1088.

Before starting Nizoral Cream, it is crucial to discuss any existing health conditions with your healthcare provider. You should be sure that your healthcare provider is aware of all your medical conditions, including if you have:

• A history of allergic reactions to other antifungals.
• Broken, inflamed, or severely damaged skin at the application site.
• Skin conditions such as eczema or psoriasis that may worsen with topical treatments.

• Are hypersensitive to ketoconazole or any component of the formulation.

Symptom improvement is often seen within a few days of starting treatment, such as reduced itching, redness, or flaking. Full resolution of fungal infections may take several weeks, depending on the condition being treated and the affected area. Continue using the ketoconazole cream for the entire prescribed duration to prevent reinfection.

When Nizoral Cream is taken with other prescription drugs, over-the-counter (OTC) medications, vitamins, and supplements, it may change how they work or increase the frequency or severity of side effects. Make sure that you tell your healthcare professional about anything that you are taking to avoid any negative drug interactions, including:

• Other topical products applied to the same area may increase irritation or reduce effectiveness.

Nizoral Cream is available as 2% ketoconazole. Ketoconazole is also available in other dosage forms, such as Nizoral Anti-Dandruff Shampoo.

It should be stored at room temperature, away from the reach of children or pets.

Nizoral Cream has been discontinued.

Yes. Ketoconazole topical cream is available as a generic version.

Do not stop using Nizoral Cream early without medical advice, even if symptoms improve. Stopping treatment too soon may allow the fungal infection to return. Speak with your healthcare provider if symptoms persist or worsen.

Nizoral Cream is likely safe when used in pregnancy since there is minimal absorption when used topically. Talk to your doctor if you are already pregnant or if you have any plans to become pregnant. Your healthcare provider will assess the potential benefits and risks before recommending use.

Talk to your doctor if you are already breastfeeding or if you have any plans to breastfeed. Avoid applying the cream to areas where an infant could come into direct contact, unless advised by a healthcare professional.