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Buy Jolessa Online
(Ethinyl Estradiol/Levonorgestrel)

What is Jolessa?

What is Jolessa?

Jolessa is a prescription birth control pill used to prevent pregnancy. It is a combination oral contraceptive that contains two hormones: ethinyl estradiol, a form of estrogen, and levonorgestrel, a type of progestin. These hormones work together to prevent ovulation and reduce the chances of pregnancy.

Jolessa is designed as an extended-cycle contraceptive. This means it is taken continuously for a longer period compared with traditional birth control pills. Instead of having a monthly menstrual cycle, people taking Jolessa usually have a menstrual period about once every three months. Jolessa does not protect against sexually transmitted diseases.

Order Jolessa online today and save!

Purchase Jolessa from Universal Drugstore today and save!

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  • All Strength's
  • 0.03/0.15mg

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Jolessa (generic Jolessa)

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Ethinyl Estradiol/Levonorgestrel 
0.03/0.15mg

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Important information about Jolessa

The active ingredients in Jolessa are levonorgestrel and ethinyl estradiol.

  • Jolessa works by using a combination of estrogen and progestin hormones to prevent pregnancy. These hormones affect several reproductive processes in the body.
  • The mechanism of action involves several effects:
  • Preventing ovulation so the ovary does not release an egg.
  • Thickening cervical mucus to make it harder for sperm to reach the egg.
  • Changing the lining of the uterus to reduce the chance of implantation.
  • Because Jolessa is an extended-cycle contraceptive, the active pills are taken for 84 consecutive days, followed by a short hormone-free interval. This extended dosing schedule results in fewer menstrual periods compared with traditional birth control pills.
  • Combination oral contraceptives such as Jolessa work best when taken consistently at the same time every day.

Follow all directions given to you by your doctor and read all documents provided, including the full Prescribing Information, FDA-Approved Product Labeling, Instructions for Use, and Medication Guide before using Jolessa. However, the following is a synopsis of the general guidelines for the use of Jolessa:

  • Take Jolessa exactly as prescribed by your healthcare provider.
  • The medication is taken by mouth once daily.
  • Take one tablet each day at the same time.
  • Jolessa packs typically contain 84 active pills followed by 7 inactive pills.
  • Begin the first cycle according to your healthcare provider’s instructions, often on the first day of your menstrual period.
  • Start a new pack immediately after finishing the previous pack.

If a dose is missed, follow the instructions in the patient information leaflet or contact your healthcare provider.

Some mild or common side effects of Jolessa include:

  • Breakthrough bleeding.
  • Irregular vaginal bleeding.
  • Breast tenderness.
  • Nausea.
  • Headache.
  • Bloating.
  • Mood changes.
  • Weight gain.

Some individuals may experience serious side effects while using Jolessa. These side effects may require immediate medical attention. If you experience any of the following, contact your healthcare provider or seek emergency medical help:

  • Heart attack symptoms such as chest pain, abdominal discomfort, sweating, nausea, and dizziness.
  • Stroke: sudden numbness or weakness in the arm, leg, or face, confusion, trouble seeing, severe headache, and trouble walking.
  • Deep vein thrombosis (blood clot in the leg) with symptoms such as leg cramp, swelling, pain, and muscle tightness.
  • Pulmonary embolism (blood clot in the lung) with symptoms like cough, chest pain, trouble breathing, and a racing heart.
  • Liver or gallbladder problems such as yellowing of the skin or the whites of the eyes (jaundice), tiredness, pain in the right upper stomach, and dark urine.
  • Allergic reactions such as swelling, rash, hives, and shortness of breath.
  • Increased risk of cervical and breast cancer.

These are not all of the possible side effects of Jolessa. You should always seek medical advice from your healthcare provider for any questions or concerns about your medical condition or treatment. Read all patient information, medication guides, or drug information sheets that come with this medication. You can also report adverse effects to the Food and Drug Administration at www.fda.gov/medwatch or 1-800-FDA-1088.

Before starting Jolessa, it is crucial to discuss any existing health conditions with your healthcare provider. You should be sure that your healthcare provider is aware of all your medical conditions, including:

  • High blood pressure or hypertension.
  • Heart disease or coronary artery disease.
  • Liver disease or hepatitis C.
  • High cholesterol or triglycerides.
  • Gallbladder disease.
  • Amenorrhea.
  • A history of blood clots or pulmonary embolism.
  • Breast cancer or other hormone-related cancers.
  • Jolessa should not be used as protection against sexually transmitted diseases. Other methods, such as condoms, may be needed to prevent infections.
  • Patients should speak with a health care professional before using herbal products or supplements that may affect hormone levels.

Boxed Warning

Combination hormonal contraceptives carry a serious safety warning related to smoking and liver risks. Cigarette smoking significantly increases the risk of serious cardiovascular side effects, especially in women over 35 years of age and those who smoke heavily (15 or more cigarettes per day). For this reason, women using oral contraceptives are strongly advised not to smoke. In addition, these contraceptives should not be used alongside certain hepatitis C treatments containing ombitasvir, paritaprevir, ritonavir, with or without dasabuvir, as this combination may lead to harmful increases in liver enzymes (ALT).

Jolessa should not be used in individuals who have:

  • A history of blood clots or thromboembolism.
  • Known or suspected breast cancer.
  • Severe liver disease.
  • Known hypersensitivity to ethinyl estradiol, levonorgestrel, or any ingredient in the medication.
  • Uncontrolled high blood pressure or other major heart problems.
  • Females over the age of 35 who smoke or have migraine headaches.
  • Migraine headaches with aura.
  • Currently pregnant.
  • Undiagnosed vaginal bleeding.
  • Take certain hepatitis C medications that contain ombitasvir, paritaprevir, and ritonavir, with or without dasabuvir.

Your healthcare provider will review your medical history to determine whether Jolessa is appropriate.

Jolessa may begin preventing ovulation shortly after starting the first cycle when taken correctly. However, additional contraceptive protection, such as spermicide or another method, may be recommended during the first week of use.

When Jolessa takes other prescription drugs, over-the-counter medications, vitamins, and supplements, it may change how they work or increase the frequency or severity of side effects. Make sure that you tell your healthcare professional about anything that you are taking to avoid any negative drug interactions, including:

  • Rifampin or rifabutin, which may decrease hormone levels and reduce contraceptive effectiveness.
  • Carbamazepine, phenytoin, barbiturates, felbamate, or topiramate, which may increase hormone metabolism and reduce effectiveness.
  • Ritonavir or nevirapine, which may alter hormone concentrations.
  • St. John’s wort, which may reduce contraceptive effectiveness.
  • Griseofulvin, which may decrease hormone levels.
  • Cyclosporine, which may have altered levels when taken with estrogen-containing contraceptives.
  • Atorvastatin.
  • Dasabuvir.
  • Temazepam.
  • Tizanidine.

Patients should inform their healthcare provider about all supplements and herbal products they take.

Jolessa is available as oral tablets in extended-cycle packs.

Typical packs contain:

84 active tablets containing levonorgestrel and ethinyl estradiol.

7 inactive tablets.

These tablets are taken daily as part of a 91-day contraceptive cycle.

It should be stored at room temperature, away from the reach of children or pets.

Jolessa has been manufactured by Teva Pharmaceuticals and other pharmaceutical companies.

Yes, generic versions of levonorgestrel and ethinyl estradiol extended-cycle contraceptives are available.

If you wish to stop taking Jolessa, speak with your healthcare provider. They can help determine the safest way to discontinue the medication and discuss alternative forms of contraception if needed.

Stopping the medication may result in the return of regular menstrual cycles.

Jolessa should not be used during pregnancy. If pregnancy occurs while taking the medication, contact your healthcare provider for medical advice.

Talk to your doctor if you are already breastfeeding or if you have any plans to breastfeed. Your healthcare provider will determine whether Jolessa is appropriate during breastfeeding.

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Important information about buying Jolessa from UniversalDrugstore™

Once you complete your order, we process, verify, and dispatch your medication. You’ll receive email updates at each stage, including tracking details once your order ships. If any additional documentation is needed (such as a valid prescription), we’ll contact you promptly. Once approved, your order is charged and delivered directly to your doorstep.

Orders are typically processed within 1–3 business days once all required documents are received and approved. Standard delivery times range from 10–18 business days, depending on your location.

Yes! Once your medication ships, you will receive an email with tracking information so you can monitor your shipment every step of the way.

Our Customer Care team is available 24/7 to assist with any order-related concerns or questions. If you experience delays, missing items, or need support, contact us using the details provided in your confirmation email.

All orders are shipped in discreet, plain packaging to protect your privacy. Medications are securely packaged to prevent damage and ensure they arrive in top condition.

Yes. We use cold-chain shipping methods to safely transport temperature-sensitive medications, ensuring they maintain proper storage conditions throughout delivery.

Shipping costs vary depending on your location and shipping method. Free shipping promotions may be available—check the checkout page for the latest offers. Orders above $100 going to a US destination will receive free shipping.

Currently, we do not bill Medicare or Medicaid directly. However, we provide detailed receipts and documentation that you can submit to your insurance provider for potential reimbursement.

Universal Drugstore does not bill private health insurance directly, but we provide a detailed invoice that you can submit to your insurer for possible reimbursement. Many insurers will accept Universal Drugstore’s documents, but if you have any questions, check with your insurance company prior to purchasing.

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Universal Drugstore offers many generic alternatives that provide the same active ingredients at a lower cost. Search for your medication and compare pricing for generic vs. brand-name options. Generic availability depends on the medication.

If your medication requires a prescription, you must upload it online, via email, or fax. Over-the-counter (OTC) medications do not require a prescription. All prescription medication purchases require a valid and approved prescription. The Universal Drugstore customer care team can contact your doctor directly to get your prescription, and ensure all information is up to date.

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Yes! If your prescription includes refills, you can reorder quickly by logging into your account and selecting your medication for a hassle-free refill process. Always refill your medication proactively and ontime, to ensure you do not run out of important medication.

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Medical Disclaimer

The information, including but not limited to, text, graphics, images and other material contained on this website are for informational purposes to increase health awareness only. No material on this site is intended to be a substitute for professional medical advice, diagnosis or treatment. 



Always seek the advice of your physician or other qualified health care provider with any questions you may have regarding a medical condition or treatment and before undertaking a new health care regimen, and never disregard professional medical advice or delay in seeking it because of something you have read on this website.