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Buy Ortho Tri-Cyclen Online
(Ethinyl Estradiol/Norgestimate)

What is Ortho Tri-Cyclen?

What is Ortho Tri-Cyclen?

Ortho Tri-Cyclen is a prescription birth control pill used to prevent pregnancy. It is a combination oral contraceptive that contains two hormones: ethinyl estradiol (an estrogen) and norgestimate (a progestin). This triphasic formulation provides varying hormone levels throughout the menstrual cycle to closely mimic the body’s natural hormone changes.

In addition to preventing pregnancy, Ortho Tri-Cyclen may help regulate the menstrual cycle, reduce painful periods (dysmenorrhea), and improve acne in some individuals. It does not protect against sexually transmitted diseases.

This hormonal contraceptive is taken daily and should be used consistently for best effectiveness.

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Purchase Ortho Tri-Cyclen from Universal Drugstore today and save!

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  • All Strength's
  • 0.035/0.18mg, 0.035/0.215mg, 0.035/0.25mg

Ortho Tri-Cyclen brand

Ortho Tri-Cyclen 21 Day 
0.035/0.18mg, 0.035/0.215mg, 0.035/0.25mg

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Product of Canada

Product of Canada

Marketed as Tri-Cyclen 21 Day in Canada.

Ortho Tri-Cyclen 28 Day 
0.035/0.18mg, 0.035/0.215mg, 0.035/0.25mg

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Currently Unavailable

Prescription Required
Product of Canada

Product of Canada

Marketed as Tri-Cyclen 28 Day in Canada.

Ethinyl Estradiol/Norgestimate (generic Ortho Tri-Cyclen)

What are generics?

Ethinyl Estradiol/Norgestimate 
0.035/0.18mg, 0.035/0.215mg, 0.035/0.25mg

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Prescription Required
Product of Canada

Product of Canada

Marketed as Tri-Jordyna 28 day in Canada.

Also available from Canada
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Prescription Required
Product of Canada

Product of Canada

Marketed as Tri-Jordyna 21 day in Canada

Trinessa 28 Day (generic Ortho Tri-Cyclen)

What are generics?

Ethinyl Estradiol/Norgestimate 
0.035/0.18mg, 0.035/0.215mg, 0.035/0.25mg

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Currently Unavailable

Prescription Required
Product of United States

Product of United States

Also available from United States
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Product of United States

Product of United States

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Important information about Ortho Tri-Cyclen

The active ingredient in Ortho Tri-Cyclen is ethinyl estradiol and norgestimate.

Ortho Tri-Cyclen works through several mechanisms of action. It prevents ovulation by suppressing the release of eggs from the ovaries. It also thickens cervical mucus, making it harder for sperm to reach the egg, and alters the uterine lining to reduce the likelihood of implantation. These combined effects make it an effective birth control pill when taken as directed.

Follow all directions given to you by your doctor and read all documents provided, including the full Prescribing Information, FDA-Approved Product Labeling, Instructions for Use, and Medication Guide before using Ortho Tri-Cyclen. However, the following is a synopsis of the general guidelines for the use of Ortho Tri-Cyclen:

  • Take one tablet by mouth at the same time every day.
  • Follow the order in the tablet dispenser, as this is a triphasic pill with changing hormone levels.
  • You may start using Ortho Tri-Cyclen on the first day of your menstrual period (day 1 start) or the first Sunday after your period begins (Sunday start).
  • Take all active pills followed by the inactive pills as directed in the pack.
  • If you miss pills, follow the instructions provided in your medication guide or contact your healthcare provider.
  • Use a backup birth control method such as spermicide if you miss doses or during the first cycle.
  • Start a new pack immediately after finishing the previous one.

Some mild or common side effects of Ortho Tri-Cyclen seen in clinical trials as compared to placebo include:

  • Nausea.
  • Headache.
  • Breast tenderness.
  • Bloating.
  • Weight gain.
  • Breakthrough bleeding or spotting between menstrual periods.

Some individuals may experience serious side effects while using Ortho Tri-Cyclen. These side effects may require immediate medical attention. If you experience any of the following, contact your healthcare provider or seek emergency medical help:

  • Blood clots, including deep vein thrombosis or pulmonary embolism.
  • Chest pain or symptoms of a heart attack.
  • Severe headache or vision changes.
  • Signs of stroke such as weakness or difficulty speaking.
  • High blood pressure or hypertension.
  • Liver problems, including jaundice or liver tumors.
  • Allergic reaction including hives or swelling.

These are not all of the possible side effects of Ortho Tri-Cyclen. You should always seek medical advice from your healthcare provider for any questions or concerns about your medical condition or treatment. Read all patient information, medication guides, or drug information sheets that come with this medication. You can also report adverse effects to the Food and Drug Administration at www.fda.gov/medwatch or 1-800-FDA-1088.

Before starting Ortho Tri-Cyclen, it is crucial to discuss any existing health conditions with your healthcare provider. You should be sure that your healthcare provider is aware of all your medical conditions, including if you have:

  • A history of blood clots or thromboembolic disorders.
  • Heart disease, coronary artery disease, or high blood pressure.
  • Liver disease or liver problems.
  • Breast cancer or other hormone-sensitive conditions such as cervical cancer or endometrial cancer..
  • High cholesterol or triglycerides.
  • Gallbladder disease.
  • Diabetes or metabolic conditions.

Additional precautions:

  • Smoking increases the risk of serious cardiovascular events, especially in women over 35 years of age.
  • Monitor blood pressure regularly while using hormonal contraceptives.
  • Contact lenses may become uncomfortable due to fluid retention.
  • This medication does not protect against sexually transmitted diseases.
  • Irregular bleeding or missed periods may occur, especially during the first year of use.

Boxed Warning

Cigarette smoking increases the risk of serious cardiovascular events from combination oral contraceptives. This risk increases with age and the number of cigarettes smoked, particularly in women over 35 years of age.

  • History of blood clots, thrombosis, or thromboembolic disorders.
  • Known or suspected breast cancer or estrogen-dependent neoplasia.
  • Liver tumors or active liver disease.
  • Uncontrolled high blood pressure.
  • Undiagnosed abnormal vaginal bleeding.
  • Pregnancy.

When started on the first day of your menstrual cycle, Ortho Tri-Cyclen may begin working right away. If started at another time, it may take up to 7 days to become fully effective, and a backup method should be used during that time.

When Ortho Tri-Cyclen is taken with other prescription drugs, over-the-counter medications, vitamins, and supplements, it may change how they work or increase the frequency or severity of side effects. Make sure that you tell your healthcare professional about anything that you are taking to avoid any negative drug interactions, including:

  • Carbamazepine, which may reduce contraceptive effectiveness by increasing hormone metabolism.
  • Ritonavir, which may alter hormone levels and reduce effectiveness.
  • Certain herbal products such as St. John’s wort, which may decrease effectiveness of hormonal contraceptives.

Ortho Tri-Cyclen is available as:

  • Oral tablets in a 28-day pack with triphasic dosing (varying hormone levels).

Each pack includes:

21 active pills with increasing doses of norgestimate and a consistent dose of ethinyl estradiol.

7 inactive reminder pills.

There is also a lower-estrogen version called Ortho Tri-Cyclen Lo, which contains 0.025 mg of ethinyl estradiol instead of 0.035 mg.

It should be stored at room temperature, away from the reach of children or pets.

Ortho Tri-Cyclen is manufactured by Janssen Pharmaceuticals, a subsidiary of Johnson & Johnson.

Yes, generic versions containing ethinyl estradiol and norgestimate are available.

You may stop taking Ortho Tri-Cyclen at any time, but it is best to consult your healthcare provider first.

  • Stopping the medication may result in changes to your menstrual cycle.
  • Use an alternative birth control method if you do not wish to become pregnant.

Ortho Tri-Cyclen should not be used during pregnancy. Talk to your doctor if you are already pregnant or if you have any plans to become pregnant. They will know or recommend what is best for you.

Hormonal contraceptives may reduce breast milk production and pass into breast milk, so caution is advised. Talk to your doctor if you are already breastfeeding or if you have any plans to breastfeed. They will know or recommend what is best for you.

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Important information about buying Ortho Tri-Cyclen from UniversalDrugstore™

Once you complete your order, we process, verify, and dispatch your medication. You’ll receive email updates at each stage, including tracking details once your order ships. If any additional documentation is needed (such as a valid prescription), we’ll contact you promptly. Once approved, your order is charged and delivered directly to your doorstep.

Orders are typically processed within 1–3 business days once all required documents are received and approved. Standard delivery times range from 10–18 business days, depending on your location.

Yes! Once your medication ships, you will receive an email with tracking information so you can monitor your shipment every step of the way.

Our Customer Care team is available 24/7 to assist with any order-related concerns or questions. If you experience delays, missing items, or need support, contact us using the details provided in your confirmation email.

All orders are shipped in discreet, plain packaging to protect your privacy. Medications are securely packaged to prevent damage and ensure they arrive in top condition.

Yes. We use cold-chain shipping methods to safely transport temperature-sensitive medications, ensuring they maintain proper storage conditions throughout delivery.

Shipping costs vary depending on your location and shipping method. Free shipping promotions may be available—check the checkout page for the latest offers. Orders above $100 going to a US destination will receive free shipping.

Currently, we do not bill Medicare or Medicaid directly. However, we provide detailed receipts and documentation that you can submit to your insurance provider for potential reimbursement.

Universal Drugstore does not bill private health insurance directly, but we provide a detailed invoice that you can submit to your insurer for possible reimbursement. Many insurers will accept Universal Drugstore’s documents, but if you have any questions, check with your insurance company prior to purchasing.

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Universal Drugstore offers many generic alternatives that provide the same active ingredients at a lower cost. Search for your medication and compare pricing for generic vs. brand-name options. Generic availability depends on the medication.

If your medication requires a prescription, you must upload it online, via email, or fax. Over-the-counter (OTC) medications do not require a prescription. All prescription medication purchases require a valid and approved prescription. The Universal Drugstore customer care team can contact your doctor directly to get your prescription, and ensure all information is up to date.

Yes! You can add multiple medications to your cart, including prescription, OTC, and pet medications, and complete your purchase in a single checkout process.

Yes! If your prescription includes refills, you can reorder quickly by logging into your account and selecting your medication for a hassle-free refill process. Always refill your medication proactively and ontime, to ensure you do not run out of important medication.

Yes! We offer:

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The information, including but not limited to, text, graphics, images and other material contained on this website are for informational purposes to increase health awareness only. No material on this site is intended to be a substitute for professional medical advice, diagnosis or treatment. 



Always seek the advice of your physician or other qualified health care provider with any questions you may have regarding a medical condition or treatment and before undertaking a new health care regimen, and never disregard professional medical advice or delay in seeking it because of something you have read on this website.