Benadryl Cream

The active ingredient in Benadryl Cream is diphenhydramine hydrochloride (also known as diphenhydramine HCL). Diphenhydramine is an antihistamine that works by blocking the effects of histamine, which is the substance that causes the itch. Through this mechanism, Benadryl Cream is an effective itch-stopping cream for mosquito bites, minor burns, rashes, and other minor skin irritations.

Follow all directions given to you by your doctor and read all documents provided, including the full Prescribing Information, FDA-Approved Product Labeling, Instructions for Use, and Medication Guide, before using Benadryl Cream. However, the following is a synopsis of the general guidelines for the use of Benadryl Cream:

• For adults and children 2 years of age and older, clean the affected area with soap and water. Apply Benadryl Cream to the affected area no more than 3 to 4 times a day. Wash your hands after using the topical cream.
• If your symptoms don’t improve after 7 days of using Benadryl Cream or symptoms worsen, stop use and contact a healthcare professional.
• Benadryl Cream is meant for external use only. If swallowed, get medical attention or call your local poison control center.

The most common side effects of Benadryl Cream include:

• Application site reactions like burning, crusting, peeling, or dry skin

Some individuals may experience serious side effects while using Benadryl Cream. These side effects may require immediate medical attention. If you experience any of the following, contact your healthcare provider or seek emergency medical help:

• Allergic reaction. Signs include hives, rash, or swelling of the face, lips, or tongue.

These are not all of the possible side effects of Benadryl Cream. You should always seek medical advice from your healthcare provider for any questions or concerns about your medical condition or treatment. Read all patient information, medication guides, or drug information sheets that come with this medication. You can also report adverse effects to the Food and Drug Administration at www.fda.gov/medwatch or 1-800-FDA-1088.

Before starting Benadryl Cream, it is crucial to discuss any existing health conditions with your healthcare provider. You should be sure that your healthcare provider is aware of all your medical conditions, including whether you have:

• Allergic to any medications, supplements, preservatives, or food.
• Chicken pox or measles. This is because these rashes cover large areas of the body, and too much Benadryl Cream may be absorbed through the skin.

• Do not use on large areas of the body.
• Do not use on broken skin.
• Younger than 2 years old.
• If you are taking any other medication that also contains diphenhydramine.
• Allergic to diphenhydramine or any medications containing diphenhydramine.

You will start to feel relief from itchy skin in 15 to 30 minutes of applying the cream on the affected area.

When Benadryl Cream is taken with other prescription drugs, over-the-counter medications, vitamins, and supplements, it may change how they work or increase the frequency or severity of side effects. Make sure that you tell your healthcare professional about anything that you are taking to avoid any negative drug interactions, including:

• Oral or topical antihistamines.
• Medications containing diphenhydramine.

Benadryl Cream is available as 2% diphenhydramine hydrochloride.

Store Benadryl Cream at room temperature, out of reach of children and pets.

Kenvue manufactures Benadryl Cream.

There are generic versions of Benadryl Cream available.

Benadryl Cream does not have any withdrawal effects and should only be used for short periods, so you can stop using it once the minor skin irritation has healed. If you are unsure of when to stop taking Benadryl Cream, contact your healthcare professional.

Human data is limited, but Benadryl Cream is likely safe when used in pregnancy based on animal data. Talk to your doctor if you are already pregnant or if you have any plans to become pregnant. They will know or recommend what is best for you.

Although oral diphenhydramine is excreted in breastmilk, it is unknown if Benadryl Cream (topical diphenhydramine) is excreted into breastmilk. Talk to your doctor if you are already breastfeeding or if you have any plans to breastfeed. They will know or recommend what is best for you.