Celebrexand/or alternativesChemical Ingredient: Celecoxib
What is a generic medication?
Generic medications are significantly discounted copies of brand name medication that have the same active ingredients, intended use, dosage, side effects, effects, and route of administration as the original brand name medication. In other words, generic medications have the same pharmacological effects as their brand-name counterparts. Over half of all prescribed medications are for generic medications.
- Marketed as Celecoxib-Pfizer 100mg in New Zealand
- Product of New Zealand • Shipped from New Zealand
- Prescription Required
- Manufactured by An MHRA approved UK Generic Manufacturer
- Product of United Kingdom • Shipped from United Kingdom
- Prescription Required
- Manufactured by Pfizer
- Product of Australia • Shipped from Vanuatu
- Prescription Required
- Manufactured by An MHRA approved UK Generic Manufacturer
- Product of United Kingdom • Shipped from United Kingdom
- Prescription Required
Celebrex Helps Treat the Following Conditions:
Osteoarthritis affects different joints in the body – most often the knees, hips, lower back, and neck. It is caused by the wearing out of cartilage, a tissue which covers the ends of all bones in the body. When cartilage is damaged, joints begin to rub against each other, causing swelling and pain.
Osteoarthritis commonly affects people over 65 years. There is no cure for osteoarthritis but symptoms can be managed.
Rheumatoid arthritis is an autoimmune disorder where the immune system mistakenly attacks the lining of joints. The result is swelling, pain, and eventual deformity and erosion of bones. This condition may also manifest in eye, skin, lung, and blood vessel damage. There is no cure for rheumatoid arthritis but symptoms can be managed successfully if treatment starts early on.
Pain is a physical warning sign linked to an injury or illness in the body. Acute pain is usually the result of a specific cause, like surgery, dental procedures, and fractures. Acute pain disappears when the problem is resolved. Acute pain is different than chronic pain, which lasts longer than six months and can be debilitating.
Celebrex Active Ingredient
Celebrex is a nonsteroidal anti-inflammatory drug (NSAID) used to treat pain and swelling. Its active ingredient is celecoxib, a COX-2 inhibitor, which blocks the enzyme responsible for producing prostaglandins. Decreasing prostaglandins helps to reduce pain and swelling.
Celebrex in the News
Ten-year Study Eases Concerns about Celebrex, Heart Risk
A recent study has relieved fears that celecoxib, a pain-relieving nonsteroidal anti-inflammatory drug, increases heart risks more than older NSAIDs.
Celebrex was compared to two other brand-name drugs containing naproxen and ibuprofen. Scientists evaluated how patients with arthritis – who needed to take such drugs routinely to manage pain – responded to the medications.
Patients' risk of heart failure, heart attack, and stroke were monitored. It turned out that Celebrex was not only just as effective as the other two drugs but also safer. The results were published in the New England Journal of Medicine.
Nearly a thousand medical centers around the world participated, with researchers studying more than 24,000 osteoarthritis and rheumatoid arthritis patients for a decade.
The overall likelihood of a patient experiencing negative side effects was 28 percent higher in patients taking ibuprofen, and 15 percent higher in patients taking naproxen (compared to those taking celecoxib).
FDA Approves Celebrex in Generic Versions
The FDA approved the first generic versions of the non-steroidal anti-inflammatory painkiller, Celebrex.
Celebrex is manufactured by the drug company, Pfizer, and was their fourth-best-selling drug in 2013, with sales of US$2.92 billion. It is prescribed to treat pain, rheumatoid arthritis, osteoarthritis, and other conditions.
The approved generic versions of Celebrex are manufactured by Teva Pharmaceuticals and Mylan. With generic drugs, patients can save as much as 30 to 80 percent on their prescriptions.
Celebrex General Information
Celebrex is prescribed to alleviate acute pain, as well as menstrual pain and discomfort. The drug reduces pain and swelling and helps patients perform normal daily activities.
Celebrex is also prescribed to patients with osteoarthritis and rheumatoid arthritis. Patients with chronic conditions such as arthritis should ask their doctor about non-drug treatments or other medications that might provide pain relief.
Before starting treatment, patients should discuss the risks and benefits of taking this medication with their doctor.
In rare cases, nonsteroidal anti-inflammatory drugs like Celebrex may increase the risk of heart attack or stroke. This risk increases in patients who use heart medications regularly, or who already have heart disease. Smokers, diabetics, patients with high blood pressure, and those with a family history of heart disease face an elevated risk.
Patients should not take this medication immediately before or after heart bypass surgery.
In rare cases, Celebrex may cause serious bleeding in the stomach or intestines. This risk is higher in older adults. Bleeding may occur at any time during treatment, without warning.
Patients should stop this medication and seek immediate medical help in the event they notice any of the following side effects: bloody or black stools, persistent stomach pain, and vomit that looks like coffee grounds.
The same applies for symptoms such as pain in the chest, jaw, or left arm, and shortness of breath, unusual sweating, weakness on one side of the body, sudden vision changes, and slurred speech.
The information on this page is not a replacement for a consultation with a physician, qualified to treat this condition and prescribe medication. The information is supplied by a third party, independent from this website and only serves to raise awareness about this condition and point out basic information regarding treatment.
The website cannot take responsibility for the reliability or medical efficacy of the information provided. As mentioned above, patients should seek medical attention to ensure effective and safe treatment.
Not all products are shipped by our contracted Canadian pharmacy. The source country, shipping country, or drug manufacturer may vary depending on availability.
The website also sources from dispensaries around the world. Products can be sourced from a number of countries. Patients should note that different items within an order can be shipped from different jurisdictions, depending on availability and cost at the time an order was placed.
How to Use Celebrex
Celebrex should be taken exactly as prescribed by a doctor. The dosage depends on the patient’s medical condition and response to treatment.
Most patients are prescribed one or two daily oral doses, usually with food. This decreases the chance of stomach upset. This medication should be taken with a full glass of water. Patients should not lie down for ten minutes after taking Celebrex.
Patients should take the lowest effective dose, and only for the prescribed length of time.
Those suffering from arthritis may need to take Celebrex for up to two weeks before they get the full benefit.
Patients who take Celebrex on an "as needed" basis (rather than a regular schedule) should remember that pain medications work best when taken at the first signs of pain. The medication may not work as well if patients wait until the pain worsens.
Before starting treatment, patients need to discuss the possibility of allergic reactions to Celebrex. They should mention whether they are allergic to aspirin or any other non-steroidal anti-inflammatory drugs (NSAIDs) like ibuprofen. A history of allergic reactions to COX-2 inhibitors should be discussed with the treating physician. Patients should also mention any known sensitivity to sulfonamides.
It is vital to discuss the patient’s medical history, especially relating to liver disease, stomach bleeding, ulcers, and recurring heartburn. Patients should report asthma, especially if they have a history of breathing problems after taking aspirin (or other NSAIDs).
It is important to report heart conditions like angina or heart attack, as well as high blood pressure, stroke, anemia, bleeding problems, and nasal polyps.
Prolonged use of NSAID medications may cause kidney problems. Older adults and patients who already suffer from kidney disease are, particularly at risk. This is also the case with patients who have heart failure. The likelihood of kidney problems is also higher in patients who are dehydrated or take diuretic medications.
Patients should drink plenty of fluids to prevent dehydration. Symptoms like changes in the amount of urine may signify kidney problems. Notify your doctor immediately in the event of such symptoms.
Celebrex may cause stomach bleeding. This risk is exacerbated in smokers and those who drink alcohol daily. Patients should limit alcohol consumption and smoking.
Before surgery or certain dental procedures, patients should tell their doctor or dentist about any prescription drug, over-the-counter medication, and herbal product they are taking.
Older adults may be more sensitive to the negative side effects of Celebrex, especially regarding stomach bleeding and kidney problems.
For treatment of children with systemic onset juvenile rheumatoid arthritis, Celebrex should be used with caution. There may be an increased risk of disseminated intravascular coagulation, a very serious bleeding problem. Parents should seek immediate medical help if their child develops sudden bleeding, bruising, or bluish skin in the fingers or toes.
Before starting treatment, women of childbearing age should discuss the benefits and risks of Celebrex with their doctor. Risks can include trouble conceiving and a possibility of miscarriage. Patients should tell their doctor in the event they are pregnant or are planning to become pregnant.
Celebrex should be used only when clearly needed during pregnancy. It is not recommended for use during the first and last trimesters of pregnancy. Doing so may harm the unborn baby and interfere with labor and delivery.
This medication passes into breast milk. Women should consult their doctor before breastfeeding.
Celebrex Missed Dose
Patients who miss a dose of Celebrex should take it as soon as they remember. If this happens near the time for the next dose, patients should skip the missed dose and proceed as usual. Patients should not double up on the dose in order to catch up.
Drug interactions may change the way Celebrex works, increasing the risk of side effects. Before starting treatment, patients need to discuss the full list of medications and supplements they are taking with their doctor.
Celebrex may increase the risk of bleeding when taken with blood thinning medications like Coumadin, Lovenox, and Pradaxa. The same may happen when Celebrex is taken together with antiplatelet drugs like clopidogrel.
Celebrex may interact negatively with the blood pressure medication aliskiren and with ACE inhibitors such as captopril and lisinopril. Celebrex should not be taken together with diuretics (for example, furosemide), with lithium, and with cidofovir – a medication prescribed to treat a certain eye infection in AIDS patients.
Taking Celebrex with a class of drugs, known as angiotensin II receptor blockers, has the same effect. Angiotensin II receptor blockers are prescribed to control high blood pressure, prevent heart failure and deal with kidney failure in diabetics. Examples include the medicines Diovan and Cozaar.
Patients should check the ingredient list of any prescription or over-the-counter pain and fever relievers they plan on taking. Such medications may contain aspirin, naproxen, or ibuprofen. These drugs are similar to Celebrex and may increase the risk of side effects when taken together.
If directed by their doctor to take low doses of aspirin to prevent heart attack and stroke, patients should continue to do so unless told otherwise.
Celebrex Side Effects
Most patients are able to use Celebrex safely and without serious negative side effects.
Common side effects include gas and stomach upset. Patients should alert their doctor if these symptoms persist or worsen.
This medication may raise blood pressure. Patients should monitor their blood pressure regularly and inform their doctor if results are high.
Serious side effects can include severe headache, difficulty swallowing, and pain, swelling, or warmth in the groin or calf area. Some patients may develop kidney problems, which can manifest in symptoms like changes in the amount of urine. It is important to watch for symptoms of heart failure, like the swelling of ankles or feet, unusual tiredness, and unusual or sudden weight gain.
In rare cases, patients may develop serious, possibly fatal liver disease. These symptoms can include dark urine, loss of appetite, and persistent nausea or vomiting. Additional symptoms include severe stomach pain, and yellowing eyes or skin. Seek medical help in the event of such symptoms.
Serious allergic reactions to Celebrex are rare, yet patients should be aware of allergy symptoms such as rash, itching and swelling, severe dizziness, and trouble breathing.
Celebrex should be stored at room temperature, away from light and moisture. Do not store in the bathroom. Keep away from children and pets.
Unwanted medication should be disposed of properly and should not be poured into drains or flushed down the toilet. Patients should consult a pharmacist or their local waste disposal company to find out more about safe disposal methods.
Celebrex Drug Information
Celebrex is a nonsteroidal anti-inflammatory drug (NSAID), specifically a COX-2 inhibitor, which relieves pain and swelling (inflammation). Celebrex is used to treat arthritis, acute pain, and menstrual pain and discomfort. The pain and swelling relief provided by Celebrex helps you perform more of your normal daily activities. If you are treating a chronic condition such as arthritis, ask your doctor about non-drug treatments and/or using other medications to treat your pain. Celebrex works by blocking the enzyme in your body that makes prostaglandins. Decreasing prostaglandins helps to reduce pain and swelling.
Nonsteroidal anti-inflammatory drugs (including celecoxib) may rarely increase the risk of a heart attack or stroke. This effect can happen at any time while taking Celebrex but is more likely if you take it for a long time. The risk may be greater if you have heart disease or increased risk for heart disease (for example, due to smoking, family history of heart disease, or conditions such as high blood pressure or diabetes). Do not take Celebrex right before or after heart bypass surgery (CABG). Also, Celebrex may rarely cause serious (rarely fatal) bleeding from the stomach or intestines. This effect can occur without warning symptoms at any time while taking Celebrex. Older adults may be at higher risk for this effect. (See also Precautions and Drug Interactions sections.)bloody or black/tarry stools, persistent stomach/abdominal pain, vomit that looks like coffee grounds, chest/jaw/left arm pain, shortness of breath, unusual sweating, weakness on one side of the body, sudden vision changes, slurred speech. Talk with your doctor or pharmacist about the risks and benefits of treatment with Celebrex.
How to Use Celebrex
Read the Medication Guide provided by your pharmacist before you start using celecoxib and each time you get a refill. If you have any questions, ask your doctor or pharmacist. Take Celebrex by mouth as directed by your doctor, usually once or twice daily. To decrease the chance of stomach upset, Celebrex is best taken with food. The Dosage of Celebrex is based on your medical condition and response to treatment. Take Celebrex at the lowest effective dose and only for the prescribed length of time (. Take Celebrex with a full glass of water (8 ounces or 240 milliliters) unless your doctor directs you otherwise. Do not lie down for at least 10 minutes after taking Celebrex. For certain conditions (such as arthritis), it may take up to two weeks of taking Celebrex regularly before you get the full benefit. If you are taking Celebrex on an "as needed" basis (not on a regular schedule), remember that pain medications work best if they are used as the first signs of pain occur. If you wait until the pain has worsened, the medication may not work as well.
Before taking celecoxib, tell your doctor or pharmacist if you are allergic to it; or to aspirin, other NSAIDs (such as ibuprofen), other COX-2 inhibitors; or if you have any other allergies. may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details. Before using Celebrex, tell your doctor or pharmacist your medical history,asthma (including a history of worsening breathing after taking aspirin or other NSAIDs), liver disease, stomach/intestine/esophagus problems (such as bleeding, ulcers, recurring heartburn), heart disease (such as angina, heart attack), high blood pressure, stroke, blood disorders (such as anemia, bleeding/clotting problems), growths in the nose (nasal polyps). Kidney problems can sometimes occur with the use of NSAID medications, including celecoxib. Problems are more likely to occur if you are dehydrated, have heart failure or kidney disease, are an older adult, or if you take certain medications (see also Drug Interactions section). Drink plenty of fluids as directed by your doctor to prevent dehydration and tell your doctor right away if you have a change in the amount of urine. This medicine may cause stomach bleeding. Daily use of alcohol and tobacco, especially when combined with this medicine, may increase your risk for stomach bleeding. Limit alcohol and smoking. Consult your doctor or pharmacist for more information. Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). Older adults may be more sensitive to the side effects of Celebrex, especially stomach bleeding and kidney problems. Caution is advised when using Celebrex for children with a certain type of arthritis (systemic onset juvenile rheumatoid arthritis) because they may be at increased risk for a very serious bleeding/clotting problem (disseminated intravascular coagulation). Get medical help right away if your child develops sudden bleeding/bruising or bluish skin in the fingers/toes. Before using Celebrex, women of childbearing age should talk with their doctor(s) about the benefits and risks (such as miscarriage, trouble getting pregnant). Tell your doctor if you are pregnant or if you plan to become pregnant. During pregnancy, Celebrex should be used only when clearly needed. It is not recommended for use during the first and last trimesters of pregnancy due to possible harm to the unborn baby and interference with normal labor/delivery. Celebrex passes into breast milk. While there have been no reports of harm to nursing infants, consult your doctor before breast-feeding.
If you miss a dose of Celebrex, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch up.
Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.aliskiren, ACE inhibitors (such as captopril, lisinopril), angiotensin II receptor blockers (such as valsartan, losartan), cidofovir, lithium, "water pills" (diuretics such as furosemide). Celebrex may increase the risk of bleeding when taken with other drugs that also may cause bleeding. Examples include anti-platelet drugs such as clopidogrel, "blood thinners" such as dabigatran/enoxaparin/warfarin, among others. Check all prescription and nonprescription medicine labels carefully since many medications contain pain relievers/fever reducers (aspirin, NSAIDs such as naproxen or ibuprofen). These drugs are similar to celecoxib and may increase your risk of side effects if taken together. However, if your doctor has directed you to take low-dose aspirin to prevent heart attack or stroke (usually at dosages of 81-325 milligrams a day), you should continue taking the aspirin unless your doctor instructs you otherwise. Ask your doctor or pharmacist for more details.
Celebrex Side Effects
Stomach upset or gas may occur. If either of these effects persists or worsens, tell your doctor or pharmacist promptly. Remember that your doctor has prescribed Celebrex because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using Celebrex do not have serious side effects. Celebrex may raise your blood pressure. Check your blood pressure regularly and tell your doctor if the results are high. Tell your doctor right away if you have any serious side effects,severe headache, pain/swelling/warmth in the groin/calf, signs of kidney problems (such as change in the amount of urine), difficult/painful swallowing, symptoms of heart failure (such as swelling ankles/feet, unusual tiredness, unusual/sudden weight gain). Celebrex may rarely cause serious (possibly fatal) liver disease. Get medical help right away if you have any symptoms of liver damage,dark urine, persistent nausea/vomiting/loss of appetite, severe stomach/abdominal pain, yellowing eyes/skin. A very serious allergic reaction to Celebrex is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction,fever, swollen lymph nodes, rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.List of Celebrex side effects
Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.
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