Toradol

The active ingredient in Toradol is ketorolac. Toradol works by blocking certain substances (such as proteins and hormones) in the body that cause moderately severe pain, inflammation, fever, and swelling. More specifically, it blocks cyclooxygenase 1 and 2 (COX1 and COX2), which leads to a decreased production of prostaglandins to help relieve pain.

Follow all directions given to you by your doctor and read all documents provided, including the full Prescribing Information, FDA-Approved Product Labeling, Instructions for Use, and Medication Guide before using Toradol. However, the following is a synopsis of the general guidelines for the use of Toradol:

• Use Toradol as prescribed by your doctor by following all directions on your prescription label and reading all medication guides.
• Use the lowest dose that is useful in treating your condition.
• Toradol can be taken orally.
• Ketorolac injections are given as an infusion into a vein and are administered by a healthcare provider.
• Toradol should not be used for longer than 5 days, including both injections plus tablets. Long-term use can impair your kidneys or increase your risk of bleeding.

The most common side effects of Toradol seen in clinical trials as compared to placebo include:

• Stomach pain.
• Nausea.
• Heartburn.
• Indigestion.
• Headache.
• Constipation.
• Diarrhea.
• Drowsiness.
• Swelling.

Some individuals may experience serious side effects while using Toradol. These side effects may require immediate medical attention. If you experience any of the following, contact your healthcare provider or seek emergency medical help:

• Stomach bleeding.
• Increased risk of heart attack and stroke (chest pain spreading to your jaw or shoulder, sudden numbness or weakness on one side of the body, or slurred speech).
• Symptoms of heart failure such as swelling ankles/feet, unusual tiredness, and sudden/unusual weight gain.
• High blood pressure.
• Worsening liver problems or liver failure.
• Kidney problems.
• Allergic reactions such as hives, rash, blisters, skin rash, swelling, shortness of breath.

These are not all of the possible side effects of Toradol. You should always seek medical advice from your healthcare provider for any questions or concerns about your medical condition or treatment. Read all patient information, medication guides, or drug information sheets that come with this medication. You can also report adverse effects to the Food and Drug Administration at www.fda.gov/medwatch or 1-800-FDA-1088.

Before starting Toradol, it is crucial to discuss any existing health conditions with your healthcare provider. You should be sure that your healthcare provider is aware of all your medical conditions, including if you have:

• Heart disease, high blood pressure, high cholesterol, diabetes, or if you smoke.
• Heart attack, stroke, or blood clots.
• Stomach ulcers or stomach bleeding.
• Inflammatory bowel disease, ulcerative colitis, or Crohn's disease.
• Liver disease.
• Kidney disease (or if you are on dialysis).
• Asthma.
• Fluid retention.
• History of severe allergic reaction after taking aspirin or an NSAID.
• Scheduled to have surgery (especially a coronary artery bypass graft).
• Late pregnancy.
• Breast-feeding a baby.

Toradol is contraindicated with patients who have:

• Had peptic ulcer disease or any reported gastrointestinal bleeding in the past.
• Had an asthma or allergic-type reaction after taking aspirin or other NSAIDs.
• Bleeding in the brain.
• Coronary artery bypass graft (CABG) surgery.
• Severe kidney disease.
• It should also not be used during labor and delivery or if you are taking certain medications such as probenecid and pentoxifylline.

Patients can feel the impact of Toradol about 15 minutes after consumption since it works quickly, and its effect can last up to six hours.

When Toradol is taken with other prescription drugs, over-the-counter medications, vitamins, and supplements, it may change how they work or increase the frequency or severity of side effects causing drug interactions to occur. Make sure that you tell your healthcare professional about anything that you are taking, including:

• Probenecid.
• Pentoxifylline.
• Other NSAIDs (ibuprofen, naproxen, acetaminophen, diclofenac, aspirin, and others).
• Seizure medicines (phenytoin, carbamazepine).
• Methotrexate.
• Corticosteroids.
• A blood thinner to treat or prevent blood clots (heparin, warfarin).
• An angiotensin-converting enzyme (ACE) inhibitor.
• An angiotensin II receptor blocker (ARB).
• A selective serotonin reuptake inhibitor (SSRI) or a serotonin-norepinephrine reuptake inhibitor (SNRI).
• A diuretic or water pill.
• Lithium.

Toradol is available in the following dosage forms:

• 10 mg oral tablets.
• 15 mg/ml and 30 mg/ml injectable liquid.

The oral tablet should be stored at room temperature in a cool and dry place, between 68 F to 77 F (20 C to 25 C). Protect from light.

Toradol (ketorolac tromethamine) is given as an intramuscular (IM) injection into the muscle or intravenously (IV) into a vein. There will be no need to store it at home.

Roche Pharmaceuticals manufactures brand-name Toradol.

Toradol is available as a lower-cost generic.

Stop taking this medicine and check with your doctor immediately if you notice any serious side effects.

Talk to your doctor if you are already pregnant or if you have any plans to become pregnant. They will know or recommend what is best for you. The recommendation is not to use Toradol if you are in your third trimester of pregnancy.

Talk to your doctor if you are already breastfeeding or if you have any plans to breastfeed. They will know or recommend what is best for you. The recommendation is not to use Toradol if you are breastfeeding.