Orudis

The active ingredient in Orudis is ketoprofen, which is a nonsteroidal anti-inflammatory drug (NSAID). It blocks the inflammatory process in your body, which relieves pain and swelling.

Follow all directions given to you by your doctor and read all documents provided, including the full Prescribing Information, FDA-Approved Product Labeling, Instructions for Use, and Medication Guide before using Orudis. However, the following is a synopsis of the general guidelines for the use of Orudis:

• You can take Orudis with or without food. If it upsets your stomach, take it with meals.
• Never use immediate-release and extended-release ketoprofen capsules together since doing so increases your chance of serious side effects such as bleeding, ulcers, renal issues, and heart problems.
• If you miss a dose and use this medication regularly, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and return to your normal schedule.

The most common side effects of Orudis include:

• Nausea or vomiting.
• Stomach pain or stomach upset.
• Diarrhea.
• Constipation.
• Headaches.
• Loss of appetite.
• Urinary tract infection (UTI).
• Ringing in the ears.
• Blurred vision.
• Drowsiness.

Some individuals may experience serious side effects while using Orudis. These side effects may require immediate medical attention. If you experience any of the following, contact your healthcare provider or seek emergency medical help:

• Liver disease or liver problems: nausea, tiredness, diarrhea, and yellowing of the skin or whites of the eyes.
• Kidney problems: irregular heartbeat, shortness of breath, decreased urine output, disorientation, unusual weight gain, and weakness.
• Heart attack: chest pain, perspiration, shortness of breath, heartburn, and pain or discomfort in the jaw, neck, or shoulders.
• Gastrointestinal (GI) bleeding: dark or tarry stools, dizziness, and stomach pain.
• Serious allergic reactions: hives, swelling of the face, skin rash, tongue, or throat, and trouble breathing.
• Serious skin reactions such as Stevens-Johnson Syndrome (SJS), toxic epidermal necrolysis (TEN), and drug reaction with eosinophilia and systemic symptoms (DRESS): flu-like symptoms, a painful rash or blisters all over the body, and peeling skin.
• Stroke: weakness on one side of the body, slurred speech, loss of balance, and confusion.
• Heart failure: shortness of breath, fluid retention, and swelling in the ankles, feet, or legs.
• Increased risk of high blood pressure (hypertension).

Disclaimer: These are not all of the possible side effects of Orudis. You should always seek medical advice from your healthcare provider for any questions or concerns about your medical condition or treatment. Read all patient information, medication guides, or drug information sheets that come with this medication. You can also report adverse effects to the Food and Drug Administration at www.fda.gov/medwatch or 1-800-FDA-1088.

Before starting Orudis, it is crucial to discuss any existing health conditions with your healthcare provider. You should be sure that your healthcare provider is aware of all your medical conditions, including if you have:

• Do not take Orudis if you are allergic to ketoprofen or any other component of this medicine, aspirin or NSAIDs, or any other drugs, foods, or substances.
• Do not take it if you have ever had asthma as a result of a salicylate medicine such as aspirin or an NSAID.
• If you have any of the following health conditions, such as GI (gastrointestinal) bleeding or renal problems, or if you have recently had a heart attack, you should not use this drug.

Boxed Warning

• This medication may increase the risk of heart attacks and strokes. If you have heart disease or are at risk of developing it, your risk may increase. The danger can occur within the first few weeks of using this medication and may increase with higher doses or long-term use. Do not use this medication before or after coronary artery bypass graft (CABG) surgery.
• This medication may increase the risk of serious and perhaps fatal stomach or intestinal disorders such as ulcers or bleeding. The risk is greatest in older people and those who have had gastrointestinal.

Orudis is contraindicated in those for whom ketoprofen, aspirin, or other nonsteroidal anti-inflammatory drugs (NSAIDs) cause asthma or allergic symptoms. This medication should also not be used immediately before or after coronary artery bypass graft (CABG) surgery.

The immediate-release capsule begins acting as soon as 30 minutes after taking it. It may take 2 to 3 hours for the extended-release pill to take effect. As a result, if you need pain relief quickly, Orudis' immediate-release capsules are the way to go.

When Orudis is taken with other prescription drugs, over-the-counter medications, vitamins, and supplements, it may change how they work or increase the frequency or severity of side effects. Make sure that you tell your healthcare professional about anything that you are taking to avoid any negative drug interactions, including:

• Cyclosporine, lithium, methotrexate, probenecid, warfarin or other anticoagulants, corticosteroids, diuretics, and other nonsteroidal anti-inflammatory medications (NSAIDs) such as ibuprofen.

For osteoarthritis and rheumatoid arthritis, the recommended starting dose is 75 mg three times a day or 50 mg four times a day. The highest daily dosage is 300 mg.

For menstrual cramps and mild to moderate pain, the normal dose is 25 mg to 50 mg taken orally every 6 to 8 hours as needed. The highest daily dosage is 300 mg.

Store your Orudis at room temperature and out of reach of children.

The pharmaceutical company that manufactures Orudis is Wyeth Pharmaceuticals.

Yes, there are multiple generic versions of Orudis available.

If you want to stop taking Orudis, it is best to speak to your healthcare provider first as they may want you to taper off the medication.

Orudis may harm your unborn baby, especially if it is taken during the third trimester. If you are pregnant or may become pregnant, talk with your healthcare provider about the safest treatment option.

It is not known if Orudis is found in your breast milk or what effects it can have on your breastfed infant or milk production. Breastfeeding while on this medication is not recommended.