Oruvail

The active ingredient in Oruvail is ketoprofen. It works by inhibiting the COX enzymes, which in turn reduces the formation of prostaglandins. These prostaglandins are markers of inflammation and can cause symptoms of fever and pain. By decreasing the synthesis of prostaglandins, the symptoms of fever and pain will be reduced.

Follow all directions given to you by your doctor and read all documents provided, including the full Prescribing Information, FDA-Approved Product Labeling, Instructions for Use, and Medication Guide, before using Oruvail. However, the following is a synopsis of the general guidelines for the use of Oruvail:

• Oruvail can be taken with food to avoid any stomach upset. This analgesic should be for short-term use only and taken at the lowest effective dose to manage your pain.

The most common side effects of Oruvail include:

• Nausea
• Drowsiness
• Constipation
• Heartburn
• Stomach/gastrointestinal pain
• Headache

Some individuals may experience serious side effects while using Oruvail. These side effects may require immediate medical attention. If you experience any of the following, contact your healthcare provider or seek emergency medical help:

• Heart failure and high blood pressure: shortness of breath, swelling of the ankles, feet, or hands, blurred vision, sudden weight gain, unusual weakness or fatigue
• Stomach bleeding or perforation: vomiting blood, dark or bloody stools, and severe stomach pain
• Severe kidney problems: fatigue, dry and itchy skin, loss of appetite, urinating less than usual, bloody urine, and muscle cramps
• Stroke: chest pain, shortness of breath, weakness on one side of your body or face, and slurred speech
• Severe liver problems: abdominal swelling, yellowing of your skin or eyes (jaundice), and dark urine
• Severe allergic or skin reactions: skin rash, hives, swelling of the face/lips/mouth, reddening, peeling, or blisters

These are not all of the possible side effects of Oruvail. You should always seek medical advice from your healthcare provider for any questions or concerns about your medical condition or treatment. Read all patient information, medication guides, or drug information sheets that come with this medication. You can also report adverse effects to the Food and Drug Administration at www.fda.gov/medwatch or 1-800-FDA-1088.

Before starting Oruvail, it is crucial to discuss any existing health conditions with your healthcare provider. You should be sure that your healthcare provider is aware of all your medical conditions, including whether you have:

• High blood pressure (hypertension), heart disease, or a previous heart attack or stroke
• Fluid retention or edema
• Stomach ulcer
• Kidney problems
• Liver disease
• Asthma

Boxed Warning

• There is an increased risk of bleeding in the stomach and an increased risk of a heart attack and stroke, which could be fatal, with the use of NSAIDs like Oruvail.

• If an allergic reaction occurs to Oruvail or any of its inactive ingredients, including ethylcellulose, titanium dioxide, purified talc, or shellac. If a hypersensitivity reaction occurs, it could include signs such as blisters and fever.
• Right before or after a type of open heart surgery called coronary artery bypass graft surgery (CABG).

The immediate-release tablet will last for 6 hours, while the extended-release capsules last for 24 hours.

When Oruvail is taken with other prescription drugs, over-the-counter medications, vitamins, and supplements, it may change how they work or increase the frequency or severity of side effects. Make sure that you tell your healthcare professional about anything that you are taking to avoid any negative drug interactions, including:

• Other NSAIDs, including ibuprofen and naproxen
• Anticoagulants or medications used to prevent blood clots, like warfarin
• Acetylsalicylic acid
• Medications used for gout including Probenecid
• Lithium
• Methotrexate
• Diuretics
• Pentoxifylline
• Tacrolimus

The dosage forms include immediate-release tablets (Orudis) and extended-release capsules (Oruvail). The extended-release capsule can be taken once a day, while the immediate-release tablets can be taken 2-3 times per day when needed for pain management.

This medication should be stored at room temperature and in a dry place.

The pharmaceutical company that manufactures Oruvail is Sanofi.

There are lower-cost alternatives for the brand-name Oruvail.

Oruvail can be stopped without tapering according to the product information.

This medication can cause toxicity to the unborn baby, especially during the third trimester. Talk to your doctor if you are already pregnant or if you have any plans to become pregnant. They will know or recommend what is best for you.

Oruvail can cause significant harm to the baby and should not be used during breastfeeding as it can pass into the breast milk. Talk to your doctor if you are already breastfeeding or if you have any plans to breastfeed. They will know or recommend what is best for you.