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Rheumatrex

(Methotrexate)

Rheumatrex is an antimetabolite drug used at low doses to treat severe psoriasis or rheumatoid arthritis. It can also be used in children to treat juvenile arthritis. At high doses, it is used to treat many types of cancer, including Non-Hodgkin’s lymphoma and leukemia. It is typically taken once a week, but may be taken more often for some conditions.

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Rheumatrex brand

Rheumatrex 
2.5mg
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Australia
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Product of Australia

Marketed as Methoblastin in Australia

Methotrexate (generic Methotrexate)

What are generics?

Methotrexate 
5mg
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India
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Product of India

Marketed as Folitrax in India

Methotrexate 
7.5mg
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Country
India
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Please note that this item is currently on backorder and may require additional delivery time.
Prescription Required
Product of India

Marketed as Imutrex in India

Methotrexate (generic Rheumatrex)

What are generics?

Methotrexate 
2.5mg
Prescription Required

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United Kingdom
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Product of United Kingdom

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Important information about Rheumatrex

How does Rheumatrex work?

The active ingredient in Rheumatrex is methotrexate. When used for cancer, the high dose works by slowing the growth of cancer cells in the body. At low doses, it suppresses the immune system to slow the progress of autoimmune conditions.

How do you use Rheumatrex?

Follow all directions given to you by your doctor and read all documents provided, including the full Prescribing Information, FDA-Approved Product Labeling, Instructions for Use, and Medication Guide before using Rheumatrex. However, the following is a synopsis of the general guidelines for the use of Rheumatrex:

  • For low-dose methotrexate, used in autoimmune conditions, this medication is typically taken weekly, not daily. Contact your doctor or pharmacist if you miss a dose.
  • You may need to have lab tests done before and while taking this medication.
  • Before getting any vaccine, let your care provider know you are taking methotrexate. Avoid getting any live vaccines while on this medication.
  • You may also be prescribed folic acid while on this medication to help reduce side effects.
  • If you are using this medication to treat cancer, check your temperature often, and let your doctor know if it goes above 100.4 F.
  • Do not drink alcohol while taking this medication.
  • This medication can make you more sensitive to the sun, increasing your risk of sunburns and skin cancer. Take care to limit time in the sun during peak hours, and always wear sunscreen.
  • If you are male, do not father a child while on this medication. Use effective birth control during treatment and for at least 6 months following. Do not donate sperm during treatment and for at least 6 months following treatment.

What are the side effects of Rheumatrex?

The most common side effects of methotrexate include:

  • Mouth sores or ulcers.
  • Nausea/vomiting/diarrhea.
  • Stomach upset.
  • Dizziness.
  • Fever/chills.
  • Hair loss.
  • Low white blood cell count or platelet levels.

Some individuals may experience serious side effects while using Rheumatrex. These side effects are life-threatening and may require immediate medical attention. If you experience any of the following, contact your healthcare provider or seek emergency medical help:

  • A serious infection where your temperature is above 100.4, with or without chills, muscle aches, fast heart rate, or cough.
  • Signs of low platelets include blood in the urine or stool, unexplained bruising, cuts that take longer to stop bleeding, or nosebleeds.
  • Signs of lung disease such as shortness of breath, fever, or a cough.
  • Signs of serious liver problems include nausea, vomiting, fatigue, stomach pain, pale-coloured stool, loss of appetite, yellowing of the eyes/ skin, or dark-coloured urine.
  • Nervous system issues like severe headaches, confusion, vision changes, seizures, or difficulty talking.
  • Severe skin reactions, including painful blisters, peeling skin, a sore throat, or body aches.
  • Signs of an allergic reaction include skin rash (hives), tightness in the chest, or swelling of the mouth, lips, or tongue.

These are not all of the possible side effects of Rheumatrex. You should always seek medical advice from your healthcare provider for any questions or concerns about your medical condition or treatment. Read all patient information, medication guides, or drug information sheets that come with this medication. You can also report adverse effects to the Food and Drug Administration at www.fda.gov/medwatch or 1-800-FDA-1088.

What are the warnings or precautions for Rheumatrex?

Before starting Rheumatrex, it is crucial to discuss any existing health conditions with your healthcare provider. You should be sure that your healthcare provider is aware of all your medical conditions, including if you:

  • Have kidney problems.
  • Are alcoholic or have alcoholic liver disease.
  • Are pregnant or planning to become pregnant in the near future.
  • Are currently breastfeeding.
  • Peptic ulcer disease or ulcerative colitis.
  • Have any of: bone marrow hypoplasia, leucopenia, thrombocytopenia, or significant anemia.

Are there any contraindications with Rheumatrex?

  • Pregnancy (only if taking for a non-cancerous condition)
  • Allergy to methotrexate or any inactive ingredient in the formulation.

How long does it take Rheumatrex to work?

For rheumatoid arthritis, symptoms start to improve after 3-6 weeks, while it takes about 4-6 weeks for psoriasis. For cancer treatment, methotrexate begins working immediately.

What interacts with Rheumatrex?

When Rheumatrex is taken with other prescription drugs, over-the-counter medications, vitamins, and supplements, it may change how they work or increase the frequency or severity of side effects. Make sure that you tell your healthcare professional about anything that you are taking to avoid any negative drug interactions, including:

  • Nitrous oxide anesthesia increases the toxicity of methotrexate and should be avoided while you are on this drug.
  • Use of non-steroidal anti-inflammatory drugs (NSAIDs), including ibuprofen and naproxen, while on methotrexate is not recommended due to gastrointestinal toxicity.
  • Methotrexate should be used with caution with other Disease-Modifying Antirheumatic drugs (DMARDs) such as penicillamine, hydroxychloroquine, or sulfasalazine.
  • If you are using methotrexate for psoriasis, the use of amiodarone is contraindicated due to the risk of skin lesions.
  • L-asparaginase prevents the action of methotrexate, and should not be taken at the same time.
  • Use of methotrexate with diuretics may induce bone marrow suppression.
  • Methotrexate in combination with leflunomide may increase the risk of pancytopenia.
  • Certain medications may increase the toxicity of methotrexate, including sulfonylureas, aminobenzoic acid, salicylates, phenylbutazone, phenytoin, proton pump inhibitors such as omeprazole or pantoprazole, sulfonamides, penicillins, and tetracycline.
  • You should not receive packed red blood cells while on this medication.
  • Concurrent use of azathioprine may increase your risk of liver damage.

What doses of Rheumatrex are available?

Brand name Rheumatrex is available as 2.5mg tablets. Generic methotrexate is available in various strengths.

How do I store Rheumatrex?

It should be kept at room temperature, protected from light, and away from the reach of children or pets.

Which pharmaceutical company manufactures Rheumatrex?

It is manufactured by DAVA Pharmaceuticals.

Is there a generic version of Rheumatrex?

Yes, it is available from several manufacturers of generic drugs.

How do I stop taking Rheumatrex?

Barring any serious side effects as noted above, Rheumatrex should not be discontinued unless under the advice of a physician.

Can Rheumatrex be used if I am pregnant?

No, methotrexate is toxic to a growing fetus and can lead to fetal death and birth defects. Any person of childbearing potential on methotrexate should use an effective form of birth control before starting methotrexate. Males with partners of childbearing potential should also ensure their partners are on an appropriate birth control. You or your partner should continue using birth control for 6 months after the last dose for females or 3 months after the last dose for males. Notify your doctor if you are already pregnant, become pregnant, or if you have any plans to become pregnant.

Can Rheumatrex be used if I am breast feeding?

Methotrexate is contraindicated in nursing patients due to the risk of serious adverse reactions in nursing infants. Avoid breastfeeding during therapy and for 1 week after your final dose.

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Important information about buying Rheumatrex from UniversalDrugstore™

What happens after I place my order for Rheumatrex with Universal Drugstore?

Once you complete your order, we process, verify, and dispatch your medication. You’ll receive email updates at each stage, including tracking details once your order ships. If any additional documentation is needed (such as a valid prescription), we’ll contact you promptly. Once approved, your order is charged and delivered directly to your doorstep.

How long does it take to process and deliver my order for Rheumatrex?

Orders are typically processed within 1–3 business days once all required documents are received and approved. Standard delivery times range from 10–18 business days, depending on your location.

Can I track my order of Rheumatrex?

Yes! Once your medication ships, you will receive an email with tracking information so you can monitor your shipment every step of the way.

What should I do if there is an issue with my order for Rheumatrex?

Our Customer Care team is available 24/7 to assist with any order-related concerns or questions. If you experience delays, missing items, or need support, contact us using the details provided in your confirmation email.

How is my medication packaged to ensure privacy and safety?

All orders are shipped in discreet, plain packaging to protect your privacy. Medications are securely packaged to prevent damage and ensure they arrive in top condition.

Does Universal Drugstore ship medications that require refrigeration or special handling?

Yes. We use cold-chain shipping methods to safely transport temperature-sensitive medications, ensuring they maintain proper storage conditions throughout delivery.

What are the shipping costs, and does Universal Drugstore offer free delivery?

Shipping costs vary depending on your location and shipping method. Free shipping promotions may be available—check the checkout page for the latest offers. Orders above $100 going to a US destination will receive free shipping.

Does Universal Drugstore accept Medicare or Medicaid for prescriptions?

Currently, we do not bill Medicare or Medicaid directly. However, we provide detailed receipts and documentation that you can submit to your insurance provider for potential reimbursement.

Can I use private health insurance to cover my prescription from Universal Drugstore?

Universal Drugstore does not bill private health insurance directly, but we provide a detailed invoice that you can submit to your insurer for possible reimbursement. Many insurers will accept Universal Drugstore’s documents, but if you have any questions, check with your insurance company prior to purchasing.

How secure is my payment information when ordering from Universal Drugstore?

We use advanced SSL encryption and secure payment processing to ensure that all transactions are 100% protected against fraud and unauthorized access.

Can I order a generic alternative to Rheumatrex?

Universal Drugstore offers many generic alternatives that provide the same active ingredients at a lower cost. Search for your medication and compare pricing for generic vs. brand-name options. Generic availability depends on the medication.

Do I need a prescription to order Rheumatrex?

If your medication requires a prescription, you must upload it online, via email, or fax. Over-the-counter (OTC) medications do not require a prescription. All prescription medication purchases require a valid and approved prescription. The Universal Drugstore customer care team can contact your doctor directly to get your prescription, and ensure all information is up to date.

Can I order multiple medications at once?

Yes! You can add multiple medications to your cart, including prescription, OTC, and pet medications, and complete your purchase in a single checkout process.

Can I refill my prescription through Universal Drugstore?

Yes! If your prescription includes refills, you can reorder quickly by logging into your account and selecting your medication for a hassle-free refill process. Always refill your medication proactively and ontime, to ensure you do not run out of important medication.

Does Universal Drugstore offer discounts or price matching?

Yes! We offer:

  • Up to 80% savings on medications
  • Price match guarantee – we’ll match competitor pricing on qualifying medications
  • 10% off your first order for new customers

How can I contact Universal Drugstore for additional support?

We offer 24/7 customer support via phone, email, and chat. Visit our Contact Us page for assistance with ordering, shipping, or medication questions.

Important

The information, including but not limited to, text, graphics, images and other material contained on this website are for informational purposes to increase health awareness only. No material on this site is intended to be a substitute for professional medical advice, diagnosis or treatment. 



Always seek the advice of your physician or other qualified health care provider with any questions you may have regarding a medical condition or treatment and before undertaking a new health care regimen, and never disregard professional medical advice or delay in seeking it because of something you have read on this website.