Methotrexate Injection

and/or alternativesChemical Ingredient: Methotrexate
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  • 25mg/mL

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What is a generic medication?

Generic medications are significantly discounted copies of brand name medication that have the same active ingredients, intended use, dosage, side effects, effects, and route of administration as the original brand name medication. In other words, generic medications have the same pharmacological effects as their brand-name counterparts. Over half of all prescribed medications are for generic medications.

25mg/mL Injection

No generic is available for Methotrexate Injection with Preservative 25mg/mL.

Methotrexate Injection with Preservative 25mg/mL Injection
  • Manufactured by Mayne Pharma Canada Inc. = Faulding Canada Inc.
  • Product of Canada • Shipped from Canada
  • Prescription Required

No generic is available for Methotrexate Injection with Preservative 25mg/mL.

This product is unavailable

No generic is available for Methotrexate Injection without Preservative 25mg/mL.

Methotrexate Injection without Preservative 25mg/mL Injection
  • Manufactured by Mayne Pharma Canada Inc. = Faulding Canada Inc.
  • Product of Canada • Shipped from Canada
  • Prescription Required

No generic is available for Methotrexate Injection without Preservative 25mg/mL.

This product is unavailable

Methotrexate Injection Drug Information

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Methotrexate Injection with Preservative Drug Information

  • Methotrexate Injection Overview

    Methotrexate is used to treat certain types of cancer or to control severe psoriasis or rheumatoid arthritis. It may also be used to control juvenile rheumatoid arthritis. Methotrexate belongs to a class of drugs known as antimetabolites. It works by slowing or stopping the growth of cancer cells and suppressing the immune system. Early treatment of rheumatoid arthritis with more aggressive therapy such as methotrexate helps to reduce further joint damage and to preserve joint function.

  • Methotrexate Injection Warnings

    Methotrexate has rarely caused serious (sometimes fatal) side effects. Therefore, Methotrexate Injection should be used only to treat cancer or severe diseases caused by an overactive immune system (such as psoriasis, rheumatoid arthritis). Methotrexate formulations with preservatives must not be used for high-dose treatment or injected into the spine (intrathecal). Methotrexate has caused birth defects and death in unborn babies. Women must avoid becoming pregnant while using Methotrexate Injection. Pregnant women who have psoriasis or rheumatoid arthritis must not use methotrexate. (See also Precautions section.) If you have kidney problems or excess body water (ascites, pleural effusion), you must be closely monitored and your dose may be adjusted or stopped by your doctor. Methotrexate (usually at high dosages) has rarely caused severe (sometimes fatal) blood/bone marrow problems (decreasing your body's ability to fight infections) and stomach/intestinal disease (such as bleeding) when used at the same time as non-steroidal anti-inflammatory drugs (NSAIDs such as indomethacin, ketoprofen). Therefore, NSAIDs should not be used with high-dose methotrexate. Caution is advised if you also take aspirin. NSAIDs/aspirin may be used with low-dose methotrexate such as for the treatment of rheumatoid arthritis if directed by your doctor. If your doctor has directed you to take low-dose aspirin for heart attack or stroke prevention (usually at dosages of 81-325 milligrams a day), you should continue taking it unless your doctor instructs you otherwise. Ask your doctor or pharmacist for more details on the safe use of these drugs (such as close monitoring by your doctor, keeping the same doses of NSAIDs). In rare instances, Methotrexate Injection may also cause liver problems when Methotrexate Injection is used for long periods of time. If you are using methotrexate long term, a liver biopsy is usually recommended. Methotrexate use has rarely caused serious (sometimes fatal) side effects, such as lung problems, lung infections (Pneumocystis jiroveci pneumonia), skin reactions, diarrhea, and mouth sores (ulcerative stomatitis). (See also Side Effects section.) Lumps (tumors/abnormal growths) may very rarely appear during methotrexate use. The drug must be stopped and treatment may be needed. Tell your doctor right away if new lumps/growths occur. When used to treat tumors, methotrexate sometimes causes side effects due to the rapid destruction of cancer cells (tumor lysis syndrome). To lower your risk, drink plenty of fluids unless your doctor directs you otherwise. Also, your doctor may prescribe an additional medication. Tell your doctor right away if you have symptoms such as irregular heartbeat, low back/side pain, signs of kidney problems (such as pink/bloody urine, change in the amount of urine, painful urination), or muscle spasms/weakness. When Methotrexate Injection is used with radiation treatment, it may rarely increase the risk of tissue and bone damage. Discuss the risks and benefits of your treatment with your doctor.

  • How to Use Methotrexate Injection

    Read the Patient Information Leaflet if available from your pharmacist before you start using methotrexate and each time you get a refill. If you have any questions, ask your doctor or pharmacist. Methotrexate Injection is given by injection as directed by your doctor. The dosage, method of injection, and how often you receive Methotrexate Injection are based on your medical condition and response to treatment. For the treatment of rheumatoid arthritis or psoriasis, Methotrexate Injection is given by injection as directed by your doctor, usually once a week. For some conditions (such as rheumatoid arthritis), you may be taught to give yourself injections at home. In this case, learn all preparation and usage instructions from your health care professional. If you have any questions, ask your health care professional. Before using, check Methotrexate Injection visually for particles or discoloration. If either is present, do not use the liquid. Learn how to store and discard medical supplies safely.

  • Methotrexate Injection Precautions

    Before using methotrexate, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. Methotrexate Injection may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details. Before using Methotrexate Injection, tell your doctor or pharmacist your medical history,liver disease, kidney disease, lung disease (such as pulmonary fibrosis), alcohol use, suppressed immune system, blood cell/bone marrow disorders, stomach/intestinal diseases (such as peptic ulcer, ulcerative colitis), any active infection (including chickenpox or recent exposure to it), folic acid deficiency. Methotrexate can make you more likely to get infections or may worsen any current infections. Therefore, wash your hands well to prevent the spread of infection. Avoid contact with people who have infections that may spread to others (such as chickenpox, measles, flu). Consult your doctor if you have been exposed to an infection or for more details. Do not have immunizations/vaccinations without the consent of your doctor. Avoid contact with people who have recently received live vaccines (such as flu vaccine inhaled through the nose). To lower the chance of getting cut, bruised, or injured, use caution with sharp objects like razors and nail cutters, and avoid activities such as contact sports. Methotrexate Injection may make you dizzy or drowsy. Alcohol or marijuana (cannabis) can make you more dizzy or drowsy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Avoid alcoholic beverages. Talk to your doctor if you are using marijuana (cannabis). Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). Children may be more sensitive to the side effects of Methotrexate Injection, especially seizures. Methotrexate Injection may make you more sensitive to the sun. Limit your time in the sun. Avoid tanning booths and sunlamps. Use sunscreen and wear protective clothing when outdoors. Tell your doctor right away if you get sunburned or have skin blisters/redness. Methotrexate must not be used during pregnancy. It may harm an unborn baby. It is important to prevent pregnancy during and after treatment with methotrexate. Therefore, males and females must use reliable forms of birth control (such as condoms, birth control pills) during treatment. Males should continue to use birth control for at least 3 months after the end of treatment. Females should continue to use birth control for at least 6 months after the end of treatment. If you become pregnant or think you may be pregnant, tell your doctor right away. Methotrexate passes into breast milk and may harm a nursing infant. Therefore, breast-feeding while using Methotrexate Injection is not recommended. Consult your doctor before breast-feeding.

  • Methotrexate Injection Misdose

    For the best possible benefit, it is important to receive each scheduled dose of Methotrexate Injection as directed. If you miss a dose of Methotrexate Injection, contact your doctor or pharmacist right away to establish a new dosing schedule. Do not double the dose to catch up.

  • Methotrexate Injection Interactions

    Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.acitretin, asparaginase, chloramphenicol, leflunomide, other drugs that can cause kidney problems (such as cisplatin), other drugs that can cause liver problems (such as azathioprine, sulfasalazine, retinoids such as isotretinoin), penicillins, phenytoin, probenecid, procarbazine, pyrimethamine, sulfa medications, tetracyclines. Certain drugs that reduce stomach acid (proton pump inhibitors-PPIs such as esomeprazole, omeprazole, pantoprazole) may increase the amount of methotrexate in your blood. This effect may increase the risk of side effects, especially with high-dose methotrexate treatment. Ask your doctor or pharmacist for details and ways to lessen the risk of side effects.

  • Methotrexate Injection Side Effects

    What are Methotrexate Injection side effects?

    Side effects are physical, mental or emotional symptoms which occur in addition to or outside of the desired effect of a therapeutic treatment such as an over-the-counter or prescribed drug or medication. Side effects from Methotrexate Injection may occur at the beginning or at the end of treatment and may also depend on the length of time an individual remains on the treatment. Side effects, also known as adverse effects, are generally more likely to occur when starting treatment. Individuals may also experience side effects from Methotrexate Injection as a result of an interaction with other medications.

    Side Effects of Methotrexate Injection

    The side effects of Methotrexate Injection may vary in number and intensity for many different reasons. Factors such as age, weight, gender and ethnicity may influence the side effects of Methotrexate Injection. Also, an individual’s state of general physical health and seriousness of the disease or illness as well as an increase or decrease in dosage may lead to side effects. Further, side effects from Methotrexate Injection may also occur as a result of an interaction with certain herbal supplements, foods or drinks.

    Prescription drug side effects can be serious and may cause patients to stop the treatment. However, when side effects from the use of a prescription drug, such as Methotrexate Injection, do occur a patient should consult their physician. A physician may prescribe an additional treatment in order to control the symptoms or an adjustment in the dosage may be made. In addition, changes to diet, exercise or other lifestyle activities may help to lessen the side effects of Methotrexate Injection.

    By understanding side effects and the factors which may influence the occurrence of side effects patients are empowered to take an active role in their care. Patients who have specific questions about the side effects of Methotrexate Injection, or any other medication, should contact their physician. General information about Methotrexate Injection and the side effects associated with Methotrexate Injection are described in the following:

    Common Methotrexate Injection Side Effects

    Severe

    • bacterial sepsis
    • bacterial infection
    • thrombocytopenic disorder
    • aphthous stomatitis
    • gastrointestinal ulcer
    • gastroenteritis
    • intestinal perforation
    • gastrointestinal hemorrhage
    • skin photosensitivity
    • azotemia

    Less Severe

    • gingivostomatitis
    • anorexia
    • nausea
    • vomiting
    • dizziness
    • fatigue
    • malaise

    Less Frequent Methotrexate Injection Side Effects

    Severe

    • leukopenia
    • chemical arachnoiditis
    • leukoencephalopathy
    • interstitial pneumonitis
    • pulmonary fibrosis
    • hepatic necrosis
    • hepatic cirrhosis
    • drug-induced hepatitis
    • anemia

    Less Severe

    • abnormal hepatic function tests
    • furunculosis
    • pruritus of skin
    • alopecia
    • acne vulgaris
    • skin rash
    • chills
    • fever
    • pharyngitis
    • diarrhea

    Rare or Very Rare Methotrexate Injection Side Effects

    Severe

    • agranulocytosis
    • eosinophilia
    • increased cerebrospinal fluid pressure
    • cutaneous vasculitis
    • alveolitis
    • acute hepatic failure
    • hepatic fibrosis
    • renal failure
    • Stevens-Johnson Syndrome
    • exfoliative dermatitis
    • avascular necrosis of bone
    • proteinuria
    • toxic epidermal necrolysis
    • aplastic anemia
    • Pneumocystis jirovecii pneumonia
    • pancytopenia
    • seizure disorder
    • subacute necrotizing encephalomyelopathy
    • Erythema Multiforme
    • acute respiratory insufficiency
    • kidney disease with reduction in GFR
    • neutropenic disorder
    • pericardial effusion
    • pericarditis
    • deep venous thrombosis
    • arterial thrombosis
    • Thrombosis of Retinal Vein
    • cerebral thrombosis
    • thrombophlebitis
    • pulmonary thromboembolism
    • transient blindness
    • hemiplegia
    • encephalopathy
    • fracture
    • diabetes mellitus
    • chemotherapy-induced hyperuricemia
    • Anaphylaxis
    • Pulmonary Hemorrhage

    Less Severe

    • oligospermia
    • Stinging of Skin
    • cystitis
    • hematuria
    • headache disorder
    • drowsy
    • blurred vision
    • dysarthria
    • aphasia
    • acute confusion
    • conjunctivitis
    • arthralgias
    • libido changes
    • lymphadenopathy
    • tinnitus
    • infection
  • Methotrexate Injection Storage

    Consult the product instructions and your pharmacist for storage details. Do not store in the bathroom. Keep all medications away from children and pets. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard Methotrexate Injection when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

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