Eurax Cream vs Hydrocortisone for Itchy Skin: Which Treatment Works Better?
Dealing with itchy skin can be frustrating, especially when you’re not sur...
Cortef is a brand name for oral hydrocortisone, a corticosteroid. Adults and children take it to treat health conditions caused by inflammation or a hyperactive immune system, including rheumatoid arthritis, psoriasis, psoriatic arthritis, ulcerative colitis, allergic disorders, lupus, lung disorders, other skin conditions (e.g., Stevens-Johnson syndrome), and certain blood cell disorders such as anemia (low red blood cells) or thrombocytopenia (low platelets). Lastly, Cortef is also used in the treatment of certain cancers such as leukemia, lymphoma, and multiple myeloma.
Cortef (hydrocortisone) is available as a pill to be taken orally once a day, though dosing may vary based on your specific condition. Solu-Cortef is an intravenous (IV) form of hydrocortisone while Alkindi Sprinkle is another oral hydrocortisone formulation.
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Product of Canada
Product of Canada
Product of New Zealand
Marketed as Hydrocortisone DP in New Zealand.
Product of United States
Marketed as Hydrocortisone in United States
Product of India
Marketed as Hisone in India.
Product of United States
Marketed as Hydrocortisone in United States
Product of United States
Product of New Zealand
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The active ingredient in Cortef is hydrocortisone which is a glucocorticoid. It is also commonly classified as a corticosteroid. It's a synthetic version of cortisol, a hormone that your body naturally produces. It works by reducing particular molecules in your body that produce itching, redness, swelling, and pain.
Follow all directions given to you by your doctor and read all documents provided, including the full Prescribing Information, FDA-Approved Product Labeling, Instructions for Use, and Medication Guide before using Cortef. However, the following is a synopsis of the general guidelines for the use of Cortef:
The most common side effects of Cortef include:
Some individuals may experience serious side effects while using Cortef. These side effects may require immediate medical attention. If you experience any of the following, contact your healthcare provider or seek emergency medical help:
These are not all of the possible side effects of Cortef. You should always seek medical advice from your healthcare provider for any questions or concerns about your medical condition or treatment. Read all patient information, medication guides, or drug information sheets that come with this medication. You can also report adverse effects to the Food and Drug Administration at www.fda.gov/medwatch or 1-800-FDA-1088.
Before starting Cortef, it is crucial to discuss any existing health conditions with your healthcare provider. You should be sure that your healthcare provider is aware of any of the following:
-A thyroid condition.
Cortef begins acting about 30 minutes after taking a dose. How long it will take to reach its full effects will depend on several factors, including what condition is being treated.
When Cortef is taken with other prescription drugs, over-the-counter medications, vitamins, and supplements, it may change how they work or increase the frequency or severity of side effects. Make sure that you tell your healthcare professional about anything that you are taking to avoid any negative drug interactions, including:
The typical oral dose of hydrocortisone ranges from 20 mg to 240 mg per day and hydrocortisone tablets come in three strengths: 5 mg, 10 mg, and 20 mg. The strength your doctor prescribes depends on what condition. Your healthcare professional will adjust your dose based on your response and any negative effects.
Store Cortef at room temperature and out of reach of children.
Pfizer is the pharmaceutical company that manufactures Cortef.
There are several lower-cost generic versions available of Cortef.
Do not stop taking Cortef abruptly. Speak to your healthcare provider and they will tell you which type of tapering method is best for you.
There is not much information on taking Cortef while pregnant. Talk to your doctor if you are already pregnant or if you have any plans to become pregnant. They will know or recommend what is best for you.
Cortef can pass into your breast milk. Talk to your doctor if you are already breastfeeding or if you have any plans to breastfeed. They will know or recommend what is best for you.
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Click to joinWe ship to destinations within the United States, including Alaska and Hawaii, as well as internationally. Delivery typically takes about 2 weeks for orders shipped within the U.S. and Canada, and about 4 weeks for international orders, depending on your location and customs processing.
Once you complete your order, we process, verify, and dispatch your medication. You’ll receive email updates at each stage, including tracking details once your order ships. If any additional documentation is needed (such as a valid prescription), we’ll contact you promptly. Once approved, your order is charged and delivered directly to your doorstep.
Orders are typically processed within 1–3 business days once all required documents are received and approved. Standard delivery times range from 10–18 business days, depending on your location.
Yes! Once your medication ships, you will receive an email with tracking information so you can monitor your shipment every step of the way.
Our Customer Care team is available 24/7 to assist with any order-related concerns or questions. If you experience delays, missing items, or need support, contact us using the details provided in your confirmation email.
All orders are shipped in discreet, plain packaging to protect your privacy. Medications are securely packaged to prevent damage and ensure they arrive in top condition.
Yes. We use cold-chain shipping methods to safely transport temperature-sensitive medications, ensuring they maintain proper storage conditions throughout delivery.
Shipping costs vary depending on your location and shipping method. Free shipping promotions may be available—check the checkout page for the latest offers. Orders above $100 going to a US destination will receive free shipping.
Currently, we do not bill Medicare or Medicaid directly. However, we provide detailed receipts and documentation that you can submit to your insurance provider for potential reimbursement.
Universal Drugstore does not bill private health insurance directly, but we provide a detailed invoice that you can submit to your insurer for possible reimbursement. Many insurers will accept Universal Drugstore’s documents, but if you have any questions, check with your insurance company prior to purchasing.
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Universal Drugstore offers many generic alternatives that provide the same active ingredients at a lower cost. Search for your medication and compare pricing for generic vs. brand-name options. Generic availability depends on the medication.
If your medication requires a prescription, you must upload it online, via email, or fax. Over-the-counter (OTC) medications do not require a prescription. All prescription medication purchases require a valid and approved prescription. The Universal Drugstore customer care team can contact your doctor directly to get your prescription, and ensure all information is up to date.
Yes! You can add multiple medications to your cart, including prescription, OTC, and pet medications, and complete your purchase in a single checkout process.
Yes! If your prescription includes refills, you can reorder quickly by logging into your account and selecting your medication for a hassle-free refill process. Always refill your medication proactively and ontime, to ensure you do not run out of important medication.
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Dealing with itchy skin can be frustrating, especially when you’re not sur...
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Always seek the advice of your physician or other qualified health care provider with any questions you may have regarding a medical condition or treatment and before undertaking a new health care regimen, and never disregard professional medical advice or delay in seeking it because of something you have read on this website.

Jamie Winn, PharmD, is a licensed pharmacist and seasoned medical content reviewer with over 20 years of experience in clinical pharmacy, patient care, and healthcare leadership.
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Shirley is a Medical Writer and first-year Doctor of Pharmacy (PharmD) student at the University of Alberta, where she is building on her strong foundation in health sciences and patient care.
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