Advair HFA

(Fluticasone Propionate/Salmeterol Xinafoate)

Advair HFA is an inhaler that combines two medications used to treat chronic asthma: fluticasone, an inhaled corticosteroid, and salmeterol, a long-acting beta-agonist (LABA). It is not for the short-term relief of asthma symptoms. Side effects include headache, throat irritation, and muscle pain.

Purchase Advair HFA on Universal Drugstore and save today!

Brand Versions

Advair HFA Prescription Required

Strength
45/21mcg/Inh
Country
New Zealand
Select Quantity
Seretide Inhaler 50/25 in New Zealand is equivalent in strength to Advair HFA 45/21 in the USA. The difference is due to the strength being measured in an alternate way. The amount of medicine delivered is the same.

Marketed as Seretide Inhaler 50/25mcg/Inh in New Zealand

Advair HFA Prescription Required

Strength
115/21mcg/Inh
Country
New Zealand
Select Quantity
Seretide Inhaler 125/25 in New Zealand is equivalent in strength to Advair HFA 115/21 in the USA. The difference is due to the strength being measured in an alternate way. The amount of medicine delivered is the same.

Marketed as Seretide Inhaler 125/25mcg/Inh in New Zealand

Advair HFA Prescription Required

Strength
230/21mcg/Inh
Country
New Zealand
Select Quantity
The strength is listed as 250/25mcg in New Zealand compared to 230/21mcg in the United States. The products are identical, the strengths are simply labelled differently.

Marketed as Seretide Inhaler 250/25mcg/Inh in New Zealand

Generic Versions
What are generics?

Fluticasone Propionate/Salmeterol Xinafoate Prescription Required

Strength
45/21mcg/Inh
Country
India
Select Quantity
Seroflo Inhaler 50/25 in India is equivalent in strength to Advair HFA 45/21 in the USA. The difference is due to the strength being measured in an alternate way. The amount of medicine delivered is the same.

Marketed as Seroflo Junior Inhaler 50/25mcg/Inh in India

Fluticasone Propionate/Salmeterol Xinafoate Prescription Required

Strength
115/21mcg/Inh
Country
India
Select Quantity
Seroflo Inhaler 125/25 in India is equivalent in strength to Advair HFA 115/21 in the USA. The difference is due to the strength being measured in an alternate way. The amount of medicine delivered is the same.

Marketed as Seroflo Inhaler 125/25mcg/Inh in India

Also available from United Kingdom
Strength
115/21mcg/Inh
Country
United Kingdom
Select Quantity
Sirdupla Inhaler 125/25 in the UK is equivalent in strength to Advair HFA 115/21 in the USA. The difference is due to the strength being measured in an alternate way. The amount of medicine delivered is the same.

Marketed as Sirdupla 125/25mcg/Inh in United Kingdom

Fluticasone Propionate/Salmeterol Xinafoate Prescription Required

Strength
230/21mcg/Inh
Country
India
Select Quantity

Marketed as Seroflo Inhaler 250/25mcg/Inh in India

Also available from United Kingdom
Strength
230/21mcg/Inh
Country
United Kingdom
Select Quantity
Sirdupla Inhaler 250/25 in the UK is equivalent in strength to Advair HFA 230/21 in the USA. The difference is due to the strength being measured in an alternate way. The amount of medicine delivered is the same.

Marketed as Sirdupla 250/21mcg/Inh in United Kingdom

Don't see what you're looking for? Contact us

  • Secure SSL
  • Norton Shopping Guarantee

Important information about Advair HFA

How does Advair HFA work?

The active ingredients in Advair HFA are fluticasone propionate, an inhaled corticosteroid and salmeterol, an LABA. Inhaled corticosteroids work by targeting swelling in the lungs, preventing the release of inflammatory elements that cause the symptoms of asthma. Inhaled LABA medications are bronchodilators, which work by opening up the airways to relieve shortness of breath and cough caused by asthma.

This inhaler is not intended for sudden breathing problems and will not replace your rescue inhaler like albuterol (Ventolin HFA, ProAir HFA). It is also not recommended for people with chronic obstructive pulmonary disease (COPD), as they may benefit more from Advair Diskus.

How do you use Advair HFA?

Follow all directions given to you by your doctor and read all documents provided, including the full Prescribing Information, FDA-Approved Product Labeling, Instructions for Use, and Medication Guide, before using Advair HFA. However, the following is a synopsis of the general guidelines for the use of Advair HFA:

1. To assemble the HFA inhaler, insert the metal canister into the purple plastic actuator. Check the back of the plastic actuator to ensure you can see the counter on the canister through the window (should read either 124 or 064).

2. To open the HFA inhaler, remove the mouthpiece by squeezing the sides of the cap and pulling it straight out.

3. Before using Advair HFA for the first time, prime the inhaler by shaking it for 5 seconds and spraying into the air away from your face. Repeat four times before first use, twice if you haven’t used the inhaler for 4 weeks or more, or dropped it.

3. To use, shake the inhaler well for five seconds, and breathe out through your mouth.

4. Put the mouthpiece in your mouth and close your lips around it.

5. Push the top of the canister down while breathing in slowly and deeply through your mouth.

6. Hold your breath for as long as is comfortable, try for at least 10 seconds, then breathe out slowly.

7. Wait about 30 seconds, then repeat steps 4-7 if needed for another dose.

8. Always rinse your mouth (swish and spit) after using this inhaler, and replace the mouthpiece for storage.

9. You should clean the mouthpiece of your HFA inhaler once a week, after your evening dose, to prevent medicine build-up. To do so, remove the cap and use a dry cotton swab to wipe the small circular opening. Then use a clean, damp tissue to wipe the inside of the mouthpiece, and let it air-dry overnight.

10. Watch the dose counter, and refill your prescription when it reads 020. When the counter reads 000, there are no doses left, and you should dispose of the inhaler.

What are the side effects of Advair HFA?

The most common side effects of Advair HFA include:

  • Upper respiratory tract infection.
  • Headache.
  • Throat irritation or sore throat.
  • Dry mouth.
  • Muscle pain.
  • Bone pain.
  • Hoarseness/ voice changes.
  • Nausea/ vomiting.
  • Dizziness.

Some individuals may experience serious side effects while using Advair HFA. These side effects may require immediate medical attention. If you experience any of the following, contact your healthcare provider or seek emergency medical help:

  • Fungal infections of the mouth/ throat (thrush), which may present as white patches on the roof of your mouth - to avoid/ reduce this risk, always rinse your mouth after using this inhaler, and spit out the water (don’t swallow).
  • Pneumonia, which may present with symptoms of cough, fever, chills, and increased breathing problems.
  • Adrenal gland insufficiency, which may present with symptoms of fatigue, weakness, nausea, vomiting, and low blood pressure.
  • Serious allergic reactions which may present as rash, hives, swelling of the face, mouth, or tongue, and/ or trouble breathing.
  • Effects on the heart (increased blood pressure, irregular heartbeat, heart rate or heart rhythm, chest pain) or nervous system (tremor or nervousness).
  • Thinning or weakness of the bones (osteoporosis).
  • Eye problems such as glaucoma or cataracts - to manage this risk, you should have regular eye exams while using this medication.
  • Infections - while taking this drug, you should avoid contact with anyone who has been exposed to or is currently diagnosed with measles or chickenpox.

This medication also has the potential to cause an initial worsening of your asthma symptoms, requiring you to use your rescue inhaler more often, experience nighttime awakenings due to your symptoms, or have acute asthma attacks. Contact your physician if this occurs at any time.

These are not all of the possible side effects of Advair HFA. You should always seek medical advice from your healthcare provider for any questions or concerns about your medical condition or treatment. Read all patient information, medication guides, or drug information sheets that come with this medication. You can also report adverse effects to the Food and Drug Administration at www.fda.gov/medwatch or 1-800-FDA-1088.

What are the warnings or precautions for Advair HFA?

Before starting Advair HFA, it is crucial to discuss any existing health conditions with your healthcare provider. You should be sure that your healthcare provider is aware of all your medical conditions, including whether you have:

  • Heart problems, such as coronary artery disease or heart failure.
  • High blood pressure.
  • Seizures, or a seizure disorder.
  • Thyroid disorder.
  • Type 2 diabetes.
  • Weak bones (osteoporosis).
  • Medical conditions affecting the immune system.
  • Eye conditions such as glaucoma or cataracts.
  • Liver dysfunction.

Are there any contraindications with Advair HFA?

  • Treatment of a sudden or severe asthma attack (rescue use).
  • Allergy to fluticasone or salmeterol.
  • Chronic obstructive pulmonary disease (COPD).

How long does it take Advair HFA to work?

With the first dose of Advair HFA, you may notice improvements in your breathing within 30 minutes, but the maximum benefits from this medication are seen after a week of regular use.

What interacts with Advair HFA?

When Advair HFA is taken with other prescription drugs, over-the-counter medications, vitamins, and supplements, it may change how they work or increase the frequency or severity of side effects. Make sure that you tell your healthcare professional about anything that you are taking to avoid any negative drug interactions, including:

  • Strong CYP3A4 inhibitors, such as azole antifungals (ketoconazole, posaconazole, voriconazole), antibiotics (clarithromycin), and antivirals (ritonavir), which may increase the levels of the drug and induce heart-related side effects.
  • Monoamine oxidase inhibitors (MAOIs) or tricyclic antidepressants, such as amitriptyline, which may increase the effects of the medication on the heart.
  • Beta-blockers (labetalol, nadolol, propanolol, sotalol), which may induce bronchospasm (wheezing).
  • Diuretics, or “water pills”, when used in combination with Advair HFA, may reduce potassium levels.

What doses of Advair HFA are available?

  • Fluticasone/ salmeterol 45 mcg/21 mcg
  • Fluticasone/ salmeterol 115 mcg/21 mcg
  • Fluticasone/ salmeterol 230 mcg/21 mcg

How do I store Advair HFA?

Advair HFA should be stored at room temperature with the mouthpiece facing down, out of reach of children.

Which pharmaceutical company manufactures Advair HFA?

Advair HFA is manufactured by GSK.

Is there a generic version of Advair HFA?

Yes, there is a generic version of Advair HFA currently available. There are also similar products containing an inhaled corticosteroid (mometasone, budesonide) in combination with a LABA (formoterol, arformoterol, or vilanterol).

How do I stop taking Advair HFA?

This medication should not be discontinued abruptly, as you will have an increased risk of asthma symptoms. If, after a two-week trial, you feel this medication is not effective or you are experiencing significant side effects, talk with your physician to discuss next steps for managing your condition.

Can Advair HFA be used if I am pregnant?

Talk to your doctor if you are already pregnant or if you have any plans to become pregnant. They will know or recommend what is best for you.

Overall, as this drug is inhaled, it is expected that it does not reach high enough concentrations in the blood to cause harm to a growing fetus.

Regarding fluticasone, it is reported to be compatible with pregnancy, and experts suggest that there is a minimal risk of exposure to a growing fetus when the parent uses inhaled fluticasone. There were also no reports of effects of pre-term labour, low birth weight, or malformations.

For salmeterol, there is limited data on the risk during pregnancy, but what experts have found suggests that the risk to a growing fetus is minimal.

Can Advair HFA be used if I am breast feeding?

Talk to your doctor if you are already breastfeeding or if you have any plans to breastfeed. They will know or recommend what is best for you.

Overall, as this drug is inhaled, it is expected that it does not reach high enough concentrations in the blood to cause harm to a nursing infant.

For both fluticasone and salmeterol, there is no human data on the exposure to a nursing infant, but the properties of both drugs suggest they pose minimal risk.

Universal Drugstore Loyalty Rewards

Referral Rewards

Earn $50 by referring a friend to Universal Drug Store. $50 for you, and $50 for your friend.

Click to refer

Loyalty Rewards

Join our loyalty program, and earn loyalty reward points on each purchase to save even more.

Click to join

Important information about buying Advair HFA from UniversalDrugstore™

What happens after I place my order for Advair-hfa with Universal Drugstore?

Once you complete your order, we process, verify, and dispatch your medication. You’ll receive email updates at each stage, including tracking details once your order ships. If any additional documentation is needed (such as a valid prescription), we’ll contact you promptly. Once approved, your order is charged and delivered directly to your doorstep.

How long does it take to process and deliver my order for Advair-hfa?

Orders are typically processed within 1–3 business days once all required documents are received and approved. Standard delivery times range from 10–18 business days, depending on your location.

Can I track my order of Advair-hfa?

Yes! Once your medication ships, you will receive an email with tracking information so you can monitor your shipment every step of the way.

What should I do if there is an issue with my order for Advair-hfa?

Our Customer Care team is available 24/7 to assist with any order-related concerns or questions. If you experience delays, missing items, or need support, contact us using the details provided in your confirmation email.

How is my medication packaged to ensure privacy and safety?

All orders are shipped in discreet, plain packaging to protect your privacy. Medications are securely packaged to prevent damage and ensure they arrive in top condition.

Does Universal Drugstore ship medications that require refrigeration or special handling?

Yes. We use cold-chain shipping methods to safely transport temperature-sensitive medications, ensuring they maintain proper storage conditions throughout delivery.

What are the shipping costs, and does Universal Drugstore offer free delivery?

Shipping costs vary depending on your location and shipping method. Free shipping promotions may be available—check the checkout page for the latest offers. Orders above $100 going to a US destination will receive free shipping.

Does Universal Drugstore accept Medicare or Medicaid for prescriptions?

Currently, we do not bill Medicare or Medicaid directly. However, we provide detailed receipts and documentation that you can submit to your insurance provider for potential reimbursement.

Can I use private health insurance to cover my prescription from Universal Drugstore?

Universal Drugstore does not bill private health insurance directly, but we provide a detailed invoice that you can submit to your insurer for possible reimbursement. Many insurers will accept Unievrsal Drugstore’s documents, but if you have any questions, check with your insurance company prior to purchasing.

How secure is my payment information when ordering from Universal Drugstore?

We use advanced SSL encryption and secure payment processing to ensure that all transactions are 100% protected against fraud and unauthorized access.

Can I order a generic alternative to Advair-hfa?

Universal Drugstore offers many generic alternatives that provide the same active ingredients at a lower cost. Search for your medication and compare pricing for generic vs. brand-name options. Generic availability depends on the medication.

Do I need a prescription to order Advair-hfa?

If your medication requires a prescription, you must upload it online, via email, or fax. Over-the-counter (OTC) medications do not require a prescription. All prescription medication purchases require a valid and approved prescription.

Can I order multiple medications at once?

Yes! You can add multiple medications to your cart, including prescription, OTC, and pet medications, and complete your purchase in a single checkout process.

Can I refill my prescription through Universal Drugstore?

Yes! If your prescription includes refills, you can reorder quickly by logging into your account and selecting your medication for a hassle-free refill process. Always refill your medication proactively and ontime, to ensure you do not run out of important medication.

Does Universal Drugstore offer discounts or price matching?

Yes! We offer:

  • Up to 80% savings on medications
  • Price match guarantee – we’ll match competitor pricing on qualifying medications
  • 10% off your first order for new customers

How can I contact Universal Drugstore for additional support?

We offer 24/7 customer support via phone, email, and chat. Visit our Contact Us page for assistance with ordering, shipping, or medication questions.

Important

The information, including but not limited to, text, graphics, images and other material contained on this website are for informational purposes to increase health awareness only. No material on this site is intended to be a substitute for professional medical advice, diagnosis or treatment. 



Always seek the advice of your physician or other qualified health care provider with any questions you may have regarding a medical condition or treatment and before undertaking a new health care regimen, and never disregard professional medical advice or delay in seeking it because of something you have read on this website.