Pramox HC vs Regular Preparation H for Hemorrhoids
When hemorrhoids cause persistent pain, itching, and swelling, choosing the righ...
Pramox HC Cream is a prescription topical medication used to relieve itching, inflammation, and discomfort associated with various skin conditions. It combines two active ingredients, hydrocortisone acetate and pramoxine hydrochloride, which work together to reduce irritation and provide temporary pain relief.
This cream is often used for conditions such as eczema, minor skin irritation, allergic reactions, and other inflammatory skin conditions. It is applied directly to the affected area and is designed to provide local relief without significant effects throughout the rest of the body.
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The active ingredients in Pramox HC Cream are hydrocortisone acetate and pramoxine hydrochloride.
Hydrocortisone is a corticosteroid that works by reducing inflammation, redness, and swelling in the skin. It suppresses the immune response and decreases the release of substances that cause irritation. Pramoxine is a local anesthetic that helps relieve itching and discomfort by blocking nerve signals in the skin. Together, these ingredients provide both anti-inflammatory and soothing effects, helping to improve symptoms in affected areas.
Follow all directions given to you by your doctor and read all documents provided, including the full Prescribing Information, FDA-Approved Product Labeling, Instructions for Use, and Medication Guide before using Pramox HC Cream. However, the following is a synopsis of the general guidelines for the use of Pramox HC Cream:
Some mild or common side effects of Pramox HC Cream include:
Some individuals may experience serious side effects while using Pramox HC Cream. These side effects may require immediate medical attention. If you experience any of the following, contact your healthcare provider or seek emergency medical help:
Before starting Pramox HC Cream, it is crucial to discuss any existing health conditions with your healthcare provider. You should be sure that your healthcare provider is aware of all your medical conditions, including if you have:
Additional precautions:
PrC Cream should not be used in the following situations:
Pramox HC Cream may begin to relieve itching and irritation shortly after application due to the numbing effect of pramoxine. Anti-inflammatory effects from hydrocortisone may take a few days to become noticeable. Consistent use is important for the best results.
When Pramox HC Cream is taken with other prescription drugs, over-the-counter (OTC) medications, vitamins, and supplements, it may change how they work or increase the frequency or severity of side effects. Make sure that you tell your healthcare professional about anything that you are taking to avoid any negative drug interactions, including:
No significant drug interactions are listed in the provided sources for topical hydrocortisone and pramoxine when used as directed, due to minimal systemic absorption.
Pramox HC Cream is available in a topical dosage form that contains 1% of both hydrocortisone and pramoxine.
It should be stored at room temperature, away from the reach of children or pets.
DERMTEK PHARMA INC manufactures Pramox HC Cream.
Yes, generic versions are available that contain hydrocortisone and pramoxine in a similar topical formulation, as well as lotions, ointments, and gels.
Pramox HC Cream can usually be stopped once symptoms improve, or the prescribed treatment course is complete.
Talk to your doctor if you are already pregnant or if you have any plans to become pregnant. They will know or recommend what is best for you.
Talk to your doctor if you are already breastfeeding or if you have any plans to breastfeed. They will know or recommend what is best for you.
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Click to joinWe ship to destinations within the United States, including Alaska and Hawaii, as well as internationally. Delivery typically takes about 2 weeks for orders shipped within the U.S. and Canada, and about 4 weeks for international orders, depending on your location and customs processing.
Once you complete your order, we process, verify, and dispatch your medication. You’ll receive email updates at each stage, including tracking details once your order ships. If any additional documentation is needed (such as a valid prescription), we’ll contact you promptly. Once approved, your order is charged and delivered directly to your doorstep.
Orders are typically processed within 1–3 business days once all required documents are received and approved. Standard delivery times range from 10–18 business days, depending on your location.
Yes! Once your medication ships, you will receive an email with tracking information so you can monitor your shipment every step of the way.
Our Customer Care team is available 24/7 to assist with any order-related concerns or questions. If you experience delays, missing items, or need support, contact us using the details provided in your confirmation email.
All orders are shipped in discreet, plain packaging to protect your privacy. Medications are securely packaged to prevent damage and ensure they arrive in top condition.
Yes. We use cold-chain shipping methods to safely transport temperature-sensitive medications, ensuring they maintain proper storage conditions throughout delivery.
Shipping costs vary depending on your location and shipping method. Free shipping promotions may be available—check the checkout page for the latest offers. Orders above $100 going to a US destination will receive free shipping.
Currently, we do not bill Medicare or Medicaid directly. However, we provide detailed receipts and documentation that you can submit to your insurance provider for potential reimbursement.
Universal Drugstore does not bill private health insurance directly, but we provide a detailed invoice that you can submit to your insurer for possible reimbursement. Many insurers will accept Universal Drugstore’s documents, but if you have any questions, check with your insurance company prior to purchasing.
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Universal Drugstore offers many generic alternatives that provide the same active ingredients at a lower cost. Search for your medication and compare pricing for generic vs. brand-name options. Generic availability depends on the medication.
If your medication requires a prescription, you must upload it online, via email, or fax. Over-the-counter (OTC) medications do not require a prescription. All prescription medication purchases require a valid and approved prescription. The Universal Drugstore customer care team can contact your doctor directly to get your prescription, and ensure all information is up to date.
Yes! You can add multiple medications to your cart, including prescription, OTC, and pet medications, and complete your purchase in a single checkout process.
Yes! If your prescription includes refills, you can reorder quickly by logging into your account and selecting your medication for a hassle-free refill process. Always refill your medication proactively and ontime, to ensure you do not run out of important medication.
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We offer 24/7 customer support via phone, email, and chat. Visit our Contact Us page for assistance with ordering, shipping, or medication questions.

When hemorrhoids cause persistent pain, itching, and swelling, choosing the righ...
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Always seek the advice of your physician or other qualified health care provider with any questions you may have regarding a medical condition or treatment and before undertaking a new health care regimen, and never disregard professional medical advice or delay in seeking it because of something you have read on this website.

Jamie Winn, PharmD, is a licensed pharmacist and seasoned medical content reviewer with over 20 years of experience in clinical pharmacy, patient care, and healthcare leadership.
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Shirley is a Medical Writer and first-year Doctor of Pharmacy (PharmD) student at the University of Alberta, where she is building on her strong foundation in health sciences and patient care.
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