Clobex Shampoo

(Clobetasol Propionate)

The active ingredient in Clobex Shampoo is clobetasol propionate. Clobetasol propionate is a potent topical corticosteroid used in dermatological conditions. It helps reduce inflammation, redness, swelling, and itching associated with scalp psoriasis and other inflammatory skin conditions when used as directed.

Follow all directions given to you by your doctor and read all documents provided, including the full Prescribing Information, FDA-Approved Product Labeling, Instructions for Use, and Medication Guide before using Clobex Shampoo. However, the following is a synopsis of the general guidelines for the use of Clobex Shampoo:

• To use Clobex Shampoo, apply the shampoo on the affected areas of the scalp. Use only enough shampoo to cover the affected areas. Gently massage into the scalp to form a thin film and leave the shampoo for the prescribed contact time, usually 15 minutes. After the contact time, add water, lather, and rinse thoroughly.
• Clobex Shampoo is for external use on the scalp only.
• A non-medicated shampoo may be used afterward if recommended.
• Avoid contact with the eyes, face, groin, and other areas of the body.
• Use of Clobex Shampoo is usually limited to a short treatment period. Prolonged use or use over large areas may increase percutaneous absorption and raise the risk of systemic effects such as HPA axis suppression. Follow medical advice closely and attend follow-up visits if recommended.

Some mild or common side effects of Clobex Shampoo seen in clinical trials as compared to placebo include:

• Dry scalp or dry skin.
• Itchy scalp.
• Burning or stinging sensation.
• Redness or erythema.
• Hair thinning or hair loss.
• Miliaria.
• Folliculitis (inflammation of the hair follicles).
• Skin irritation at the application site.

Some individuals may experience serious side effects while using Clobex Shampoo. These side effects may require immediate medical attention. If you experience any of the following, contact your healthcare provider or seek emergency medical help:

• Signs of allergic reaction, such as swelling of the face, lips, or throat.
• Severe skin reactions, blistering, or worsening lesions.
• Allergic contact dermatitis.
• Stretch marks or striae developing on treated areas.
• Unusual weight gain, fatigue, or swelling may suggest adrenal suppression.
• Vision problems or eye pain, which may be linked to glaucoma or cataracts.
• Signs of skin infection, including warmth, pus, or spreading redness.
• HPA axis suppression, Cushing syndrome, or adrenal suppression.

These are not all of the possible side effects of Clobex Shampoo. You should always seek medical advice from your healthcare provider for any questions or concerns about your medical condition or treatment. Read all patient information, medication guides, or drug information sheets that come with this medication. You can also report adverse effects to the Food and Drug Administration at www.fda.gov/medwatch or 1-800-FDA-1088.

Before starting Clobex Shampoo, it is crucial to discuss any existing health conditions with your healthcare provider. You should be sure that your healthcare provider is aware of all your medical conditions, including if you have:

• Severe scalp psoriasis covering large areas of the scalp.
• Skin infections, including fungal, bacterial, or viral infections.
• A history of adrenal gland disorders.
• Glaucoma or cataracts.
• Rosacea or perioral dermatitis.
• Thinning of the skin or fragile skin.
• Known sensitivity to topical corticosteroids.

• Known hypersensitivity to clobetasol propionate or any inactive ingredients.
• Untreated skin infections at the application site.
• Use on areas of the body other than the scalp unless directed.
• Use in children under 18 years of age.

Some improvement in itching, redness, and scaling may be noticed within the first one to two weeks of treatment based on its pharmacokinetics. Maximum benefit is often seen by the end of the prescribed treatment period. If symptoms do not improve or worsen, seek medical advice.

When Clobex Shampoo is taken with other prescription drugs, over-the-counter medications, vitamins, and supplements, it may change how they work or increase the frequency or severity of side effects. Make sure that you tell your healthcare professional about anything that you are taking to avoid any negative drug interactions, including:

• Other topical corticosteroids, as combination use may increase systemic absorption.
• Medications that suppress the immune system, as infection risk may increase.

Clobex Shampoo contains clobetasol propionate 0.05%. It is supplied as a shampoo in a measured bottle, typically expressed in fl oz. The amount used per application should be the minimum needed to cover affected areas of the scalp.

The non-medicinal ingredients in Clobex Shampoo include alcohol, citric acid monohydrate, coco-betaine, polyquaternium-10, purified water, sodium citrate dihydrate, and sodium laureth sulfate.

There are other Clobex products available, including Clobex lotion and Clobex spray.

Clobex Shampoo should be stored at room temperature. Keep the bottle tightly closed and away from heat. It should be stored at room temperature, away from the reach of children or pets.

Clobex Shampoo is manufactured by Galderma.

Generic clobetasol propionate shampoo products may be available. These contain the same active ingredient and are considered therapeutically equivalent when used as directed.

Do not stop using Clobex Shampoo earlier than prescribed unless directed by your healthcare provider. Treatment is usually stopped after the recommended course is completed. Do not restart without medical advice, as repeated prolonged use may increase the risk of adverse reactions.

Talk to your doctor if you are already pregnant or if you have any plans to become pregnant. They will know or recommend what is best for you. Topical corticosteroids should be used during pregnancy only if the potential benefit outweighs the risk due to potential teratogenic effects.

Talk to your doctor if you are already breastfeeding or if you have any plans to breastfeed. They will know or recommend what is best for you. It is not known if clobetasol propionate passes into breast milk after topical use. Avoid applying to areas that may come into contact with the infant.