Anugesic HC Suppository

(Hydrocortisone Acetate/Pramoxine Hydrochloride/Zinc Sulfate)

The active ingredient in Anugesic HC Suppository is hydrocortisone acetate. Hydrocortisone acetate is a corticosteroid with anti-inflammatory properties that helps reduce swelling, redness, itching, and irritation in the rectum. Anugesic-HC suppositories also contain other active ingredients, including pramoxine hydrochloride and zinc sulfate, which help provide local numbing relief and protective effects on irritated tissue.

Follow all directions given to you by your doctor and read all documents provided, including the full Prescribing Information, FDA-Approved Product Labeling, Instructions for Use, and Medication Guide before using Anugesic HC Suppository. However, the following is a synopsis of the general guidelines for the use of Anugesic HC Suppository:

• Use Anugesic HC suppositories exactly as prescribed by your healthcare provider.
• The suppository is inserted into the rectum, usually one to two times daily, often after a bowel movement.
• Wash your hands before and after inserting the suppository. Remove the suppository from its wrapper before use. Gently insert it into the rectum, pointed end first. Remain lying down for a few minutes after insertion to allow the suppository to dissolve.
• Do not use more often or for a longer period than recommended.
• If you miss a dose, use it as soon as you remember unless it is close to the next dose. Do not use two doses at the same time.

Some mild or common side effects of Anugesic HC Suppository seen in clinical use as compared to placebo include:

• Mild burning or irritation in the rectal area.
• Dryness or discomfort in the affected area.
• Temporary itching after insertion.

Some individuals may experience serious side effects while using Anugesic HC Suppository. These side effects may require immediate medical attention. If you experience any of the following, contact your healthcare provider or seek emergency medical help:

• Signs of an allergic reaction include hives, swelling, severe itching, or difficulty breathing.
• Worsening rectal bleeding or pain.
• Persistent irritation, sores, or signs of infection.
• Severe allergic reactions involving swelling of the face or throat.

These are not all of the possible side effects of Anugesic HC Suppository. You should always seek medical advice from your healthcare provider for any questions or concerns about your medical condition or treatment. Read all patient information, medication guides, or drug information sheets that come with this medication. You can also report adverse effects to the Food and Drug Administration at www.fda.gov/medwatch or 1-800-FDA-1088.

Before starting Anugesic HC Suppository, it is crucial to discuss any existing health conditions with your healthcare provider. You should be sure that your healthcare provider is aware of all your medical conditions, including if you have:

• Frequent or unexplained rectal bleeding.
• Infections affecting the rectum or anus.
• A medical condition involving the rectal area that has not been diagnosed.
• Eye conditions such as glaucoma may worsen symptoms with prolonged use.

• A known allergy to hydrocortisone acetate, pramoxine hydrochloride, zinc sulfate, or other ingredients.
• Untreated infections in the rectal area.
• Conditions where rectal use is not advised by a healthcare professional.

Many people notice symptom relief within a few hours to a few days after starting treatment. Improvement in pain, itching, and inflammation may continue with regular use. If symptoms do not improve after several days, consult a healthcare provider.

When Anugesic HC Suppository is taken with other prescription drugs, over-the-counter medications, vitamins, and supplements, it may change how they work or increase the frequency or severity of side effects. Make sure that you tell your healthcare professional about anything that you are taking to avoid any negative drug interactions, including:

• Other rectal corticosteroids may increase the risk of side effects due to additive steroid exposure.
• Herbal products or supplements applied rectally, which may increase irritation or absorption.

Anugesic HC Suppository is available as a fixed-strength rectal suppository containing 10 mg hydrocortisone acetate along with 20 mg pramoxine hydrochloride and 10 mg zinc sulfate.

It should be stored at room temperature, away from the reach of children or pets.

Anugesic HC Suppository is manufactured by McNeil Consumer Healthcare. This product has been discontinued.

Other hydrocortisone suppositories, such as products with the generic name hydrocortisone acetate, may be available.

Anugesic HC Suppository can usually be stopped once symptoms improve or after completing the recommended course. Do not continue treatment longer than directed without medical advice.

Talk to your doctor if you are already pregnant or if you have any plans to become pregnant. They will know or recommend what is best for you. Rectal hydrocortisone should only be used during pregnancy if the potential benefit outweighs any possible risk.

Talk to your doctor if you are already breastfeeding or if you have any plans to breastfeed. They will know or recommend what is best for you. It is not known if hydrocortisone acetate from suppositories passes into breast milk in significant amounts.