Diprolene AF Cream

(Betamethasone Dipropionate Augmented)

The active ingredient in Diprolene AF Cream is augmented betamethasone dipropionate, which is a high-potency topical corticosteroid. The mechanism of action is that it works by reducing inflammation in the skin. It helps control the release of substances in the body that cause inflammation, redness, swelling, and itching. By calming this response, Diprolene AF Cream helps relieve symptoms linked to corticosteroid-responsive dermatoses such as eczema and psoriasis.

Follow all directions given to you by your doctor and read all documents provided, including the full Prescribing Information, FDA-Approved Product Labeling, and patient information, before using Diprolene AF Cream. However, the following is a synopsis of the general guidelines for the use of Diprolene AF Cream:

• Wash your hands before and after applying the cream, unless your hands are the treated area. Apply a thin film or thin layer of Diprolene AF Cream to the affected area of skin. Gently rub the cream into the skin until it disappears.
• Use the medication once or twice daily, as directed by your healthcare provider.
• Do not cover treated skin with occlusive dressings, bandages, or wraps unless instructed by your healthcare provider.
• Avoid applying the cream to the face, groin, or underarms unless specifically directed.
• Do not use Diprolene AF Cream for longer than prescribed, as prolonged use increases the risk of adverse reactions and HPA axis suppression.

Some mild or common side effects of Diprolene AF Cream seen in clinical trials include:

• Burning or stinging at the application site.
• Itching or irritation of the skin.
• Dryness or peeling.
• Redness or mild inflammation.
• Folliculitis, which may appear as small bumps around hair follicles.

Some individuals may experience serious side effects while using Diprolene AF Cream. These side effects may require immediate medical attention. If you experience any of the following, contact your healthcare provider or seek emergency medical help:

• Signs of allergic reactions, including hives, swelling, or severe itching.
• Severe skin thinning or skin atrophy.
• Development of striae or stretch marks with prolonged use.
• Worsening of skin infections or new skin infections.
• Symptoms of HPA axis suppression, such as unusual tiredness, weakness, or weight gain.
• Signs of Cushing’s syndrome, including changes in body fat distribution or facial rounding.
• Vision changes that may be linked to glaucoma when used near the eyes.
• Increased blood sugar levels in some patients, especially with prolonged use over large areas.

These are not all of the possible side effects of Diprolene AF Cream. You should always seek medical advice from your healthcare provider for any questions or concerns about your medical condition or treatment. Read all patient information that comes with this medication. You can also report adverse effects to the Food and Drug Administration at www.fda.gov/medwatch or 1-800-FDA-1088.

Before starting Diprolene AF Cream, it is crucial to discuss any existing health conditions with your healthcare provider. You should be sure that your healthcare provider is aware of all your medical conditions, including if you have:

• A history of hypersensitivity or allergic reactions to corticosteroids.
• Skin infections caused by bacteria, fungi, or viruses.
• Thinning of the skin or fragile skin areas.
• A history of glaucoma or other eye problems.
• Diabetes or problems with blood sugar control (hyperglycemia).
• Conditions affecting the adrenal glands or cortisol levels.
• Plans to use the cream on large surface areas or for prolonged periods.
• Pediatric patients may be at greater risk of systemic absorption of corticosteroids due to their higher skin surface area to body weight ratio. Pediatric use should be carefully monitored.

• Have a known hypersensitivity to betamethasone dipropionate or any component of the formulation.
• Have untreated skin infections, including viral infections such as herpes simplex.
• Have fungal or mycobacterial skin infections unless appropriate antifungal or antibacterial therapy is also used.

Many patients notice relief of itching, redness, and inflammation within a few days of starting treatment based on its pharmacokinetics. For some skin conditions, full improvement may take one to two weeks of consistent use. If symptoms do not improve within the timeframe recommended by your healthcare provider, further evaluation may be required.

When Diprolene AF Cream is taken with other prescription drugs, over-the-counter medications, vitamins, and supplements, it may change how they work or increase the frequency or severity of side effects. Make sure that you tell your healthcare professional about anything that you are taking to avoid any negative drug interactions, including:

• Other topical and systemic corticosteroids.

Diprolene AF Cream has been discontinued, but it used to be available as betamethasone dipropionate 0.05% cream. Other dosage forms are available, such as Diprolene ointment and lotions.

It should be stored at room temperature, away from the reach of children or pets.

Diprolene AF Cream has been discontinued.

Yes. The generic name for Diprolene AF Cream is betamethasone dipropionate cream.

If Diprolene AF Cream has been used for an extended period or over large areas of skin, do not stop abruptly without medical advice. Your healthcare provider may recommend gradually reducing use to prevent rebound symptoms or adrenal suppression.

Diprolene AF Cream should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Use should be limited to the smallest effective amount for the shortest duration possible. Talk to your doctor if you are already pregnant or if you have plans to become pregnant.

Talk to your doctor if you are breastfeeding or plan to breastfeed. It is not known whether topical betamethasone dipropionate is excreted in human milk. Caution is advised, and Diprolene AF Cream should not be applied to areas where the infant could come into direct contact with treated skin.