Buy Cortenema (Hydrocortisone) Online

What is Cortenema?

What is Cortenema?

Cortenema (hydrocortisone enema) is a brand-name rectal corticosteroid used to reduce inflammation in the lower part of the bowel. It is commonly prescribed for ulcerative colitis, including ulcerative proctitis. The medicine is given as an enema and works directly in the rectum and lower colon.

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  • 100mg/60mL

Cortenema brand

Cortenema 
100mg/60mL

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Product of Canada

Product of Canada

Hydrocortisone (generic Cortenema)

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Important information about Cortenema

How does Cortenema work?

The active ingredient in Cortenema is hydrocortisone, which is a topical corticosteroid. It blocks the release of inflammatory mediators and reduces immune cell activity in the intestinal lining, which decreases swelling, redness, irritation, and mucus production in the rectum and sigmoid colon. This helps relieve symptoms such as diarrhea, bleeding, and urgency in conditions like ulcerative colitis and proctitis.

How do you use Cortenema?

Follow all directions given to you by your doctor and read all documents provided, including the full Prescribing Information, FDA-Approved Product Labelling, Instructions for Use, and Medication Guide before using Cortenema. However, the following is a synopsis of the general guidelines for the use of Cortenema:

  • Cortenema is given into the rectum using the provided applicator.
  • It is usually used at bedtime so the enema can be retained as long as possible.
  • Shake the bottle before use and lie on your left side for easier administration.
  • Try to keep the medication in the rectum for at least 30 minutes or longer.
  • If you miss a dose, use it as soon as you remember unless it is close to the next scheduled dose.
  • Do not use more often than advised by your healthcare provider.

What are the side effects of Cortenema?

Some mild or common side effects of Cortenema include:

  • Rectal irritation or soreness.
  • Increased appetite or weight gain.
  • Mood swings
  • Trouble sleeping.
  • Headache.
  • Heartburn.
  • Mild swelling.
  • Hair growth.
  • Thinning of the skin, including stretch marks.

Some individuals may experience serious side effects while using Cortenema. These side effects may require immediate medical attention. If you experience any of the following, contact your healthcare provider or seek emergency medical help:

  • Signs of infection such as fever, worsening sore throat, or chills.
  • Severe allergic reactions, including hives, swelling, or trouble breathing.
  • Signs of adrenal gland problems, such as extreme tiredness or dizziness.
  • Worsening rectal pain, pus, or abscess formation.
  • Eye problems such as cataracts or glaucoma.
  • High blood pressure.
  • High blood sugar.
  • Muscle weakness.
  • Weakening of the bones (osteoporosis).
  • Sudden mental/mood changes (such as depression, mood swings, agitation).

These are not all of the possible side effects of Cortenema. You should always seek medical advice from your healthcare provider for any questions or concerns about your medical condition or treatment. Read all patient information, medication guides, or drug information sheets that come with this medication. You can also report adverse effects to the Food and Drug Administration at www.fda.gov/medwatch or 1-800-FDA-1088.

What are the warnings or precautions for Cortenema?

Before starting Cortenema, it is crucial to discuss any existing health conditions with your healthcare provider. You should be sure that your healthcare provider is aware of all your medical conditions, including:

  • A history of fungal infections.
  • Heart failure or high blood pressure.
  • Myasthenia gravis.
  • Diabetes or high blood sugar.
  • Any recent infections, including chickenpox exposure.
  • Liver disease.
  • Bleeding problems.
  • Fistulas.
  • Conditions that weaken the immune system.
  • A history of glaucoma or cataracts.

Are there any contraindications with Cortenema?

Cortenema should not be used in individuals who:

  • Have a known allergy to hydrocortisone or any component of the enema.
  • Have systemic fungal infections.

How long does it take Cortenema to work?

Some improvement may be seen within a few days, but full benefit may take several weeks, depending on the severity of ulcerative colitis.

What interacts with Cortenema?

When Cortenema is taken with other prescription drugs, over-the-counter medications, vitamins, and supplements, it may change how they work or increase the frequency or severity of side effects. Make sure that you tell your healthcare professional about anything that you are taking to avoid any negative drug interactions, including:

  • Warfarin, because hydrocortisone may affect bleeding risk.
  • Ibuprofen and other NSAIDs are associated with an increased risk of stomach irritation.
  • Supplements that affect immune function.

What doses of Cortenema are available?

Cortenema is available as a hydrocortisone rectal enema in a single-use bottle.

How do I store Cortenema?

It should be stored at room temperature, away from the reach of children or pets.

Which pharmaceutical company manufactures Cortenema?

ANI Pharmaceuticals, Inc. manufactures Cortenema.

Is there a generic version of Cortenema?

Yes. Generic hydrocortisone enema products are available.

How do I stop taking Cortenema?

Do not stop Cortenema suddenly without guidance. Your healthcare provider may adjust your schedule or taper the dose to prevent adrenal gland effects or worsening symptoms.

Can Cortenema be used if I am pregnant?

This medication should be used only when clearly needed and not for prolonged periods. Other forms of hydrocortisone (given by mouth or by injection) may harm an unborn baby. Talk to your doctor if you are already pregnant or if you have any plans to become pregnant. They will know or recommend what is best for you.

Can Cortenema be used if I am breast feeding?

It is unknown if Cortenema passes into breast milk. However, it is unlikely to harm a nursing infant. Talk to your doctor if you are already breastfeeding or if you have any plans to breastfeed. They will know or recommend what is best for you.

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Important information about buying Cortenema from UniversalDrugstore™

What happens after I place my order for Cortenema with Universal Drugstore?

Once you complete your order, we process, verify, and dispatch your medication. You’ll receive email updates at each stage, including tracking details once your order ships. If any additional documentation is needed (such as a valid prescription), we’ll contact you promptly. Once approved, your order is charged and delivered directly to your doorstep.

How long does it take to process and deliver my order for Cortenema?

Orders are typically processed within 1–3 business days once all required documents are received and approved. Standard delivery times range from 10–18 business days, depending on your location.

Can I track my order of Cortenema?

Yes! Once your medication ships, you will receive an email with tracking information so you can monitor your shipment every step of the way.

What should I do if there is an issue with my order for Cortenema?

Our Customer Care team is available 24/7 to assist with any order-related concerns or questions. If you experience delays, missing items, or need support, contact us using the details provided in your confirmation email.

How is my medication packaged to ensure privacy and safety?

All orders are shipped in discreet, plain packaging to protect your privacy. Medications are securely packaged to prevent damage and ensure they arrive in top condition.

Does Universal Drugstore ship medications that require refrigeration or special handling?

Yes. We use cold-chain shipping methods to safely transport temperature-sensitive medications, ensuring they maintain proper storage conditions throughout delivery.

What are the shipping costs, and does Universal Drugstore offer free delivery?

Shipping costs vary depending on your location and shipping method. Free shipping promotions may be available—check the checkout page for the latest offers. Orders above $100 going to a US destination will receive free shipping.

Does Universal Drugstore accept Medicare or Medicaid for prescriptions?

Currently, we do not bill Medicare or Medicaid directly. However, we provide detailed receipts and documentation that you can submit to your insurance provider for potential reimbursement.

Can I use private health insurance to cover my prescription from Universal Drugstore?

Universal Drugstore does not bill private health insurance directly, but we provide a detailed invoice that you can submit to your insurer for possible reimbursement. Many insurers will accept Universal Drugstore’s documents, but if you have any questions, check with your insurance company prior to purchasing.

How secure is my payment information when ordering from Universal Drugstore?

We use advanced SSL encryption and secure payment processing to ensure that all transactions are 100% protected against fraud and unauthorized access.

Can I order a generic alternative to Cortenema?

Universal Drugstore offers many generic alternatives that provide the same active ingredients at a lower cost. Search for your medication and compare pricing for generic vs. brand-name options. Generic availability depends on the medication.

Do I need a prescription to order Cortenema?

If your medication requires a prescription, you must upload it online, via email, or fax. Over-the-counter (OTC) medications do not require a prescription. All prescription medication purchases require a valid and approved prescription. The Universal Drugstore customer care team can contact your doctor directly to get your prescription, and ensure all information is up to date.

Can I order multiple medications at once?

Yes! You can add multiple medications to your cart, including prescription, OTC, and pet medications, and complete your purchase in a single checkout process.

Can I refill my prescription through Universal Drugstore?

Yes! If your prescription includes refills, you can reorder quickly by logging into your account and selecting your medication for a hassle-free refill process. Always refill your medication proactively and ontime, to ensure you do not run out of important medication.

Does Universal Drugstore offer discounts or price matching?

Yes! We offer:

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How can I contact Universal Drugstore for additional support?

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Medical Disclaimer

The information, including but not limited to, text, graphics, images and other material contained on this website are for informational purposes to increase health awareness only. No material on this site is intended to be a substitute for professional medical advice, diagnosis or treatment. 



Always seek the advice of your physician or other qualified health care provider with any questions you may have regarding a medical condition or treatment and before undertaking a new health care regimen, and never disregard professional medical advice or delay in seeking it because of something you have read on this website.