Arnuity Ellipta

The active ingredient in Arnuity Ellipta is fluticasone furoate inhalation powder. Fluticasone is a corticosteroid that reduces inflammation in the airways with long-term use. This improves asthma symptoms and can reduce the occurrence of asthma attacks.

Follow all directions given to you by your doctor and read all documents provided, including the full Prescribing Information, FDA-Approved Product Labeling, Instructions for Use, and Medication Guide, before using Arnuity Ellipta. However, the following is a synopsis of the general guidelines for the use of Arnuity Ellipta:

-Remove the Ellipta inhaler from the foil packaging.

-Open your Ellipta inhaler by holding the device upright and sliding the orange cover down until you hear a click. The number on the dose counter should go down by 1. This prepares the dose of Arnuity Ellipta. Do not shake the Ellipta inhaler, or you will lose the dose.

-Breathe out a complete breath, away from the inhaler.

-While holding the Ellipta inhaler upright, make a seal with your lips around the mouthpiece and take a long, steady, deep breath in through your mouth. Make sure your fingers do not cover the air vents.

-Hold your breath for as long as possible, then exhale slowly away from the inhaler.

-Close the inhaler by sliding the cover upwards until it covers the mouthpiece.

-Rinse your mouth after each use. Swish and spit out the water, do not swallow.

Arnuity Ellipta is typically used once daily. Do not use Arnuity Ellipta more than once every 24 hours. In the case of a missed dose, take the next dose when it is due. Do not take an extra dose.

If you must take more than 1 inhalation, you will need to load and inhale 1 dose at a time.

The most common side effects of Arnuity Ellipta include:

-Voice hoarseness

-Sinus, nose, or throat irritation, and other signs of a cold

-Headache

-Bronchitis (swelling of your airways)

Some individuals may experience serious side effects while using Arnuity Ellipta. These side effects may require immediate medical attention. If you experience any of the following, contact your healthcare provider or seek emergency medical help:

-White patches in your mouth or throat, which can be a sign of a fungal infection (oral thrush) that may require treatment

-Hives, skin rash, or other symptoms of a serious allergic reaction

-Vision changes and worsening glaucoma or cataracts

-Unexplained weakness and fatigue, nausea and vomiting, and feeling faint or having low blood pressure: these can be symptoms of adrenal insufficiency (a condition where your adrenal gland no longer produces enough natural steroids)

-Sudden breathing problems after using Arnuity Ellipta or worsening of your asthma symptoms

-Slowed growth in children and adolescents

These are not all of the possible side effects of Arnuity Ellipta. You should always seek medical advice from your healthcare provider for any questions or concerns about your medical condition or treatment. Read all patient information, medication guides, or drug information sheets that come with this medication. You can also report side effects to the Food and Drug Administration at www.fda.gov/medwatch or 1-800-FDA-1088.

Before starting Arnuity Ellipta, it is crucial to discuss any existing health conditions with your healthcare provider. You should be sure that your healthcare provider is aware of all your medical conditions, including whether you have:

-Eye problems

-Osteoporosis: Long-term effects of fluticasone can lead to decreased bone mineral density, and lead to weak bones

-Diabetes

-Liver problems

-Hypothyroidism

-An active viral, bacterial, or fungal infection

-Never had chicken pox or measles, and have not been vaccinated against them

The use of Arnuity Ellipta is contraindicated in people who are allergic to fluticasone furoate or other inactive ingredients of the formulation, including lactose and milk proteins.

Arnuity Ellipta is not a bronchodilator and is not meant to replace the use of a rescue inhaler in the event of acute bronchospasms or an asthma attack.

It may take up to 2 weeks to reach the full benefits of using Arnuity Ellipta.

Drug-food and drug-herb interactions with Arnuity Ellipta have not been studied. However, when Arnuity Ellipta is taken with other prescription drugs, over-the-counter meds, and supplements, it may change how they work or increase the frequency or severity of side effects. Make sure that you tell your healthcare professional about anything that you are taking to avoid any negative drug interactions, including:

-Oral corticosteroids

-Medications that inhibit the CYP3A4 enzyme, such as ritonavir, ketoconazole, or voriconazole.

Arnuity Ellipta is available in formulations containing 100 or 200 mcg of fluticasone furoate per inhalation.

Arnuity Ellipta should be stored in a dry place at room temperature between 68-77°F (20-25°C).

Arnuity Ellipta is manufactured by GlaxoSmithKline, the GSK group of companies.

Arnuity Ellipta is only available as a brand name. Fluticasone propionate is an alternative inhaled corticosteroid also used for the maintenance treatment of asthma, which is available as a generic and in several dosage forms.

You should wean off of Arnuity Ellipta gradually to prevent worsening asthma symptoms. Do not abruptly stop using Arnuity Ellipta.

The use of Arnuity Ellipta in pregnancy has not been studied. Talk to your doctor if you are already pregnant or if you have any plans to become pregnant. They will know or recommend what is best for you.

It is not known if Fluticasone is excreted into breast milk. Talk to your doctor if you are already breastfeeding or if you have any plans to breastfeed. They will know or recommend what is best for you.