Anusol Plus Suppositories

(Pramoxine Hydrochloride/Zinc Sulfate)

The active ingredients in Anusol Plus Suppositories are pramoxine hydrochloride and zinc sulfate. Pramoxine is a topical anesthetic and analgesic that works by blocking the nerve signals that cause pain. Zinc sulfate is an astringent, so it helps reduce swelling and increases healing time.

Follow all directions given to you by your doctor and read all documents provided, including the full Prescribing Information, FDA-Approved Product Labeling, Instructions for Use, and Medication Guide before using Anusol Plus Suppositories. However, the following is a synopsis of the general guidelines for the use of Anusol Plus Suppositories:

• The recommended directions of Anusol Plus Suppositories are to remove the rectal suppository from the foil wrapper and insert it into the rectum. Use one suppository in the morning, at bedtime, and after each bowel movement, up to 5 times a day.
• Do not use this product with an applicator if the applicator would cause pain when inserted into the rectum.
• For rectal use only.
• Do not use Anusol Plus Suppositories in children younger than 12 years old.
• Stop using it if your hemorrhoid symptoms do not improve within 7 days.

Some mild or common side effects of Anusol Plus Suppositories include:

• Burning, dermatitis (itchiness), and redness.
• Dryness.
• Pain or soreness.

Some individuals may experience serious side effects while using Anusol Plus Suppositories. These side effects may require immediate medical attention. If you experience any of the following, contact your healthcare provider or seek emergency medical help:

• Allergic reaction. Signs and symptoms include a rash, hives, or swelling of the face, lips, or tongue.
• Rectal bleeding.
• Signs of infection, such as sore throat, fever, swelling, heat, or pain at the application site.

These are not all of the possible side effects of Anusol Plus Suppositories. You should always seek medical advice from your healthcare provider for any questions or concerns about your medical condition or treatment. Read all patient information, medication guides, or drug information sheets that come with this medication. You can also report adverse effects to the Food and Drug Administration at www.fda.gov/medwatch or 1-800-FDA-1088.

Before starting Anusol Plus Suppositories, it is crucial to discuss any existing health conditions with your healthcare provider. You should be sure that your healthcare provider is aware of all your medical conditions, including if you have:

Allergic reactions to other hemorrhoid suppositories or ointments.

Allergic reaction to zinc sulfate, pramoxine hydrochloride, or any non-medicinal ingredients in Anusol Plus Suppositories.

It takes a few days for Anusol Plus Suppositories to start working to treat irritation, redness, and itchiness caused by hemorrhoids.

When Anusol Plus Suppositories is taken with other prescription drugs, over-the-counter medications, vitamins, and supplements, it may change how they work or increase the frequency or severity of side effects. Make sure that you tell your healthcare professional about anything that you are taking to avoid any negative drug interactions, including:

• Other suppositories and ointments like pramoxine HCl or hydrocortisone acetate.

Anusol Plus Suppositories contain 20 mg of pramoxine hydrochloride and 10 mg of zinc sulfate per suppository.

Store Anusol Plus Suppositories at room temperature, out of reach of children and pets.

Church & Dwight manufactures Anusol Plus Suppositories. There is also a patient information leaflet available on their website.

Yes, there are generic versions of Anusol Plus Suppositories. The generic name is pramoxine and zinc sulfate.

There are other Anusol products, such as Anusol-HC Suppositories, that contain the corticosteroid, hydrocortisone.

You can stop taking Anusol Plus Suppositories when your hemorrhoid symptoms improve. If your hemorrhoid symptoms, like pain, don’t improve in 10 days, please see your healthcare professional.

Anusol Plus Suppositories (pramoxine and zinc sulfate) are likely safe in pregnancy when used appropriately and for a short period. This is because it is used topically, so there is less systemic absorption; however, there are limited human studies done. Talk to your doctor if you are already pregnant or if you have any plans to become pregnant. They will know or recommend what is best for you.

It is unknown if Anusol Plus Suppositories (pramoxine and zinc sulfate) is excreted in breastmilk, but it is likely safe in lactation because there is minimal systemic absorption. It is always important to weigh the risks and benefits of using the medication. Talk to your doctor if you are already breastfeeding or if you have any plans to breastfeed. They will know or recommend what is best for you.