Prednisone

The active ingredient in Prednisone is prednisolone, which is biologically inactive and is metabolised in the liver. Prednisone is a synthetic, anti-inflammatory glucocorticoid derived from cortisone.

Prednisone not only acts as an anti-inflammatory but also suppresses the immune system, which can be beneficial in managing disorders where the immune system mistakenly attacks the body’s own tissues.

Follow all directions given to you by your doctor and read all documents provided, including the full Prescribing Information, FDA-Approved Product Labeling, Instructions for Use, and Medication Guide before using Prednisone. However, the following is a synopsis of the general guidelines for the use of Prednisone:

• Follow your doctor's instructions. Take exactly as directed. Do not change the dosage without consulting your healthcare provider.
• Prednisone must be taken with food.
• Your dosage may need to be adjusted if you are stressed, unwell, or undergo surgery. Always discuss any changes with your healthcare provider.
• To ensure accuracy, use a specific spoon or cup for measuring the dosage. If you don't have one, contact your chemist for assistance.
• Do not crush, chew, or break delayed-release tablets; swallow them whole.
• You may require regular blood tests and blood pressure monitoring while using this medication.
• Prednisone should not be stopped abruptly. Follow your doctor's recommendations for tapering your dosage.
• The medication must be stored at room temperature away from moisture and heat.

Adverse effects are more common in people taking high doses (40 mg per day or more) or over a long period. The most common side effects of Prednisone include:

• Insomnia
• Mood changes
• Increased appetite
• Nausea, stomach pain or bloating
• Headache, dizziness

Some individuals may experience serious side effects while using Prednisone. These side effects may require immediate medical attention. If you experience any of the following, contact your healthcare provider or seek emergency medical help:

• Blurred vision or eye pain.
• Increased weight gain, swelling or shortness of breath or trouble breathing.
• Severe depression, feelings of intense happiness or despair, changes in personality or behaviour, seizures (convulsions).
• Coughing up of blood or bloody stools.
• Pancreatitis - severe stomach pain spreading to your back, with or without vomiting.
• Low potassium (confusion, irregular heart rate, severe thirst, increased urination, leg soreness, muscle weakness, or limp feeling)
• High blood pressure
• High blood sugar (hyperglycemia)
• Bruising, bleeding, or delayed wound healing.
• Adrenal gland insufficiency, such as nausea, vomiting, loss of appetite, unexpected weakness or exhaustion, and dizziness.
• Allergic responses include skin rashes, itching, hives, and swelling of the face, lips, tongue, or neck.

These are not all of the possible side effects of $Drugname. You should always seek medical advice from your healthcare provider for any questions or concerns about your medical condition or treatment. Read all patient information, medication guides, or drug information sheets that come with this medication. You can also report adverse effects to the Food and Drug Administration at www.fda.gov/medwatch or 1-800-FDA-1088.

Before starting Prednisone, it is crucial to discuss any existing health conditions with your healthcare provider. You should be sure that your healthcare provider is aware of all your medical conditions, including if you have:

• Infection (particularly a virus infection like chickenpox, cold sores, or herpes).
• Liver disease (Cirrhosis)
• Kidney disease
• Heart disease, high blood pressure, and low potassium levels in the blood
• An abnormal or allergic reaction to lactose, prednisone, other drugs, foods, colours, or preservatives.
• Thyroid conditionDiabetes (high blood glucose levels)
• History of malaria
• Tuberculosis
• Osteoporosis
• Eye infections such as glaucoma, cataracts, or herpes
• Stomach ulcers, ulcerative colitis, or a history of stomach bleeding
• A muscle ailment, such as myasthenia gravis
• Depression or mental illness
• Long term steroid use can lead to bone loss (osteoporosis), especially if you smoke, do not exercise or lack vitamin D or calcium in your diet, or if there is a family history or osteoporosis.

Prednisone typically acts fast, between hours to days after the initial dose, depending on the illness being treated. If the authorised dose of prednisone is helpful in lowering inflammation, you may experience results within hours.

Prednisone's time to work may depend on:

• The condition that prednisone treats. It is sometimes used to treat chronic diseases. In this situation, it helps regulate your sickness but does not cure it.

-The dosage of prednisone. The authorised prednisone dose must be adequate to minimise inflammation. The dose of prednisone may be adjusted frequently during treatment to ensure that you are taking the lowest effective amount.

• Immediate-release prednisone formulations, available in tablet or solution form, enter your bloodstream within two hours. Delayed-release tablets need a little longer to absorb, around 6 hours. Prednisone is used to treat a variety of diseases. As a result, the time it takes for prednisone to function varies greatly depending on its composition and illness being treated.
• A prednisone dose will typically stay in your system for 16.5 to 22 hours.
• Prednisone's elimination half life is around 3 to 4 hours. This is the period required for your body to reduce plasma levels by half. A medication is typically removed from your system after approximately 5.5 half lives.

If you have a fungal infection that needs to be treated with oral antifungals, you should avoid using Prednisone. Topical antifungals may not be a concern, but always inform your doctor of any other medications you are taking before beginning this treatment.

Avoid being around persons who are unwell or infected. If you have been exposed to chicken pox or measles, call your doctor for preventive treatment. These disorders can be serious or even fatal in those who use steroids.

Do not receive vaccines while using Prednisone as the steroid medication might decrease your immune system, resulting in a increased risk of infection.

Avoid alcohol intake.

When Prednisone is taken with other prescription drugs, over-the-counter medications, vitamins, and supplements, it may change how they work or increase the frequency or severity of side effects. Make sure that you tell your healthcare professional about anything that you are taking, including:

• Amphotericin B
• Antibiotics
• Antifungal medication
• Birth control pills or other hormones
• Blood thinners such as warfarin, Coumadin
• Cyclosporine
• Digoxin, digitalis
• Diuretics
• Hepatitis C medications boceprevir or telaprevir
• HIV or AIDS medicine
• Insulin or diabetes medications you take by mouth
• Non-steroidal anti-inflammatory drug (NSAID) such as aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others
• Seizure medications such as carbamazepine, fosphenytoin, oxcarbazepine, phenobarbital, phenytoin, primidone
• Tuberculosis medications isoniazid, rifabutin, rifapentine, or rifampin

Prednisone Tablets, USP are available in the 10 mg strength which contain these inactive ingredients; lactose monohydrate, magnesium stearate, pregelatinized starch, sodium lauryl sulphate, and sodium starch glycolate. Additionally, Prednisone Tablets USP, 20 mg includes FD & C yellow #6 aluminium lake HT 15-18%.

Your medication should be stored at room temperature, between 15 and 30 degrees Celsius (59 and 86 degrees Fahrenheit) as well as kept out of reach of light.

Keep the container tightly closed. Discard any unused medication after its expiration date.

Prednisone is manufactured by Jubilant Cadista Pharmaceuticals Inc.

Prednisone is solely accessible as a generic medication; all brand-names (Deltasone, Predone, Sterapred, Sterapred DS) have been discontinued.

It is highly advised to not stop Prednisone abruptly and to rather taper off the medication. Some conditions may become worse if this medication is suddenly stopped. Also, you may experience symptoms such as nausea, weakness, weight loss, fatigue, headache, muscle pain, and dizziness.

Prednisone should be decreased gradually over days, weeks, or months to avoid Prednisone withdrawal symptoms caused by a shortage of the natural steroid cortisol.

Speak to your healthcare provider for a recommended taper schedule as it differs with each dosage.

Talk to your doctor if you are already pregnant or if you have any plans to become pregnant. They will know or recommend what is best for you.

Prednisone can be used during pregnancy at a low dose and for short-term use. However, there are hazards to using Prednisone while pregnant. For example, if you have fluid retention or high blood pressure during pregnancy, Prednisone could worsen your condition.

Talk to your doctor if you are already breastfeeding or if you have any plans to breastfeed. They will know or recommend what is best for you.

The amounts of prednisone in breastmilk are extremely low. There have been no reports of harmful effects in breastfed infants from maternal corticosteroid usage while breastfeeding. Although it is commonly advised to avoid nursing for 4 hours following a dose, this is unnecessary because prednisone milk levels are extremely low. Corticosteroids administered systemically or injected into joints or the breast have been shown to produce a temporary reduction in lactation.